Abstract：
Lewy body disease (LBD) is the second most common neurodegenerative disorder in patients older than 65 years. LBD is characterized by heterogeneous symptoms like fluctuation in attention, visual hallucinations, Parkinsonism, and REM sleep behaviour disorders. Considering the relevant social impact of the disease, identifying effective non-pharmacological treatments is becoming a priority. The aim of this systematic review was to provide an up-to-date literature review of the most effective non-pharmacological treatments in patients with LBD, focussing on evidence-based interventions.
Following PRISMA criteria, we carried out a systematic search through three databases (PubMed, Cochrane Libraries, and PEDro) including physical therapy (PT), cognitive rehabilitation (CR), light therapy (LT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), deep brain stimulation (DBS). All studies were qualitatively assessed using standardized tools (CARE and EPHPP).
We obtained a total of 1,220 studies of which 23 original articles met eligibility criteria for inclusion. The total number of LBD patients included was 231; mean age was 69.98, predominantly men (68%). Some PT studies highlighted improvements in motor deficits. CR produced significant improvements in mood, cognition, and patient\'s quality of life and satisfaction. LT outlined a partial trend of improvements in mood and sleep quality. DBS, ECT, and TMS showed some partial improvements mainly on neuropsychiatric symptoms, whereas tDCS provided partial improvements in attention.
This review highlights the efficacy of some evidence-based rehabilitation studies in LBD; however, further randomized controlled trials with larger samples are needed to provide definitive recommendations.
Following PRISMA criteria, we carried out a systematic search through three databases (PubMed, Cochrane Libraries, and PEDro) including physical therapy (PT), cognitive rehabilitation (CR), light therapy (LT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), deep brain stimulation (DBS). All studies were qualitatively assessed using standardized tools (CARE and EPHPP).
We obtained a total of 1,220 studies of which 23 original articles met eligibility criteria for inclusion. The total number of LBD patients included was 231; mean age was 69.98, predominantly men (68%). Some PT studies highlighted improvements in motor deficits. CR produced significant improvements in mood, cognition, and patient\'s quality of life and satisfaction. LT outlined a partial trend of improvements in mood and sleep quality. DBS, ECT, and TMS showed some partial improvements mainly on neuropsychiatric symptoms, whereas tDCS provided partial improvements in attention.
This review highlights the efficacy of some evidence-based rehabilitation studies in LBD; however, further randomized controlled trials with larger samples are needed to provide definitive recommendations.
摘要：
背景：路易体病（LBD）是65岁以上患者中第二常见的神经退行性疾病。LBD的特征是异质性症状，如注意力波动，视觉幻觉,帕金森病,和快速眼动睡眠行为障碍。考虑到该疾病的相关社会影响，确定有效的非药物治疗正在成为一个优先事项。本系统综述的目的是提供LBD患者最有效的非药物治疗的最新文献综述。专注于基于证据的干预措施。
方法：遵循PRISMA标准，我们通过三个数据库(PubMed，Cochrane图书馆,和PEDro）包括物理治疗（PT），认知康复（CR），光疗法（LT），经颅直流电刺激（tDCS），经颅磁刺激(TMS),电惊厥治疗(ECT),深部脑刺激（DBS）。所有研究均使用标准化工具（CARE和EPHPP）进行定性评估。
结果：我们共获得了1,220项研究，其中23篇原始文章符合纳入资格标准。纳入的LBD患者总数为231人；平均年龄为69.98岁，主要为男性（68％）。一些PT研究强调了运动缺陷的改善。CR显著改善了情绪，认知，以及患者的生活质量和满意度。LT概述了改善情绪和睡眠质量的部分趋势。DBS,ECT,TMS显示出一些部分改善，主要是神经精神症状，而tDCS在注意力方面提供了部分改进。
结论：这篇综述强调了一些循证康复研究在LBD中的疗效；然而，需要进一步的更大样本的随机对照试验来提供明确的建议.
方法：遵循PRISMA标准，我们通过三个数据库(PubMed，Cochrane图书馆,和PEDro）包括物理治疗（PT），认知康复（CR），光疗法（LT），经颅直流电刺激（tDCS），经颅磁刺激(TMS),电惊厥治疗(ECT),深部脑刺激（DBS）。所有研究均使用标准化工具（CARE和EPHPP）进行定性评估。
结果：我们共获得了1,220项研究，其中23篇原始文章符合纳入资格标准。纳入的LBD患者总数为231人；平均年龄为69.98岁，主要为男性（68％）。一些PT研究强调了运动缺陷的改善。CR显著改善了情绪，认知，以及患者的生活质量和满意度。LT概述了改善情绪和睡眠质量的部分趋势。DBS,ECT,TMS显示出一些部分改善，主要是神经精神症状，而tDCS在注意力方面提供了部分改进。
结论：这篇综述强调了一些循证康复研究在LBD中的疗效；然而，需要进一步的更大样本的随机对照试验来提供明确的建议.
