Abstract：
There is a lack of methods for investigating the autonomic nerves of the gastrointestinal tract. Our aim was to explore a novel test measuring visceral sensory evoked potentials (EPs) in response to rapid balloon distention in the rectum and compare it to established tests for diabetic neuropathy.
Participants with longstanding type 2 diabetes, newly onset, untreated diabetes <1 year, and matched controls, were included. Tests included cardiovascular reflex tests, orthostatic blood pressure, electrical skin conductance assessment, sural nerve testing and monofilament test. The rectal balloon distention pressure at earliest sensation and threshold of unpleasantness were identified and used to elicit mechanical EPs.
The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found.
Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.
Participants with longstanding type 2 diabetes, newly onset, untreated diabetes <1 year, and matched controls, were included. Tests included cardiovascular reflex tests, orthostatic blood pressure, electrical skin conductance assessment, sural nerve testing and monofilament test. The rectal balloon distention pressure at earliest sensation and threshold of unpleasantness were identified and used to elicit mechanical EPs.
The pressure at earliest sensation was higher in people with diabetes, 0.038 (0.012) bar vs. controls 0.030 (0.009) bar, p = 0.002, and in people with signs of peripheral neuropathy, 0.045 (0.014) bar, p < 0.01. Clinical correlations between EP amplitude and latency, and other tests were found.
Rectal hyposensitivity was associated with both longstanding and early diabetes, indicating enteric sensory dysfunction already in early stages of diabetes. Correlation analyses may indicate that central afferent processing is affected in parallel with peripheral neuronal function.
摘要：
目的：缺乏研究胃肠道自主神经的方法。我们的目的是探索一种新颖的测试，该测试测量内脏感觉诱发电位（EP）以响应直肠中快速球囊扩张，并将其与已建立的糖尿病神经病变测试进行比较。
方法：长期2型糖尿病患者，新发病，未经治疗的糖尿病<1年，和匹配的控件，包括在内。测试包括心血管反射测试，体位血压,皮肤电导评估，腓肠神经测试和单丝测试。确定了最早感觉和不愉快阈值时的直肠球囊扩张压力，并用于引起机械EP。
结果：糖尿病患者的最早感觉压力较高，0.038(0.012)条与控制0.030(0.009)条，p=0.002，在有周围神经病变迹象的人群中，0.045(0.014)条,p<0.01。EP幅度和潜伏期的临床相关性，和其他测试被发现。
结论：直肠低敏感性与长期和早期糖尿病有关，表明肠道感觉功能障碍已经在糖尿病的早期阶段。相关分析可能表明，中枢传入处理与周围神经元功能同时受到影响。
方法：长期2型糖尿病患者，新发病，未经治疗的糖尿病<1年，和匹配的控件，包括在内。测试包括心血管反射测试，体位血压,皮肤电导评估，腓肠神经测试和单丝测试。确定了最早感觉和不愉快阈值时的直肠球囊扩张压力，并用于引起机械EP。
结果：糖尿病患者的最早感觉压力较高，0.038(0.012)条与控制0.030(0.009)条，p=0.002，在有周围神经病变迹象的人群中，0.045(0.014)条,p<0.01。EP幅度和潜伏期的临床相关性，和其他测试被发现。
结论：直肠低敏感性与长期和早期糖尿病有关，表明肠道感觉功能障碍已经在糖尿病的早期阶段。相关分析可能表明，中枢传入处理与周围神经元功能同时受到影响。
