PDF(Pubmed)
Abstract：
The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of childhood asthma and wheezing among aged 18 months to 3 years. Then, we conducted a case-control study based on population to explore the association between prenatal different AT exposure levels and childhood asthma and wheezing. The association was assessed by generalized additive models and logistic regression models, and stratified analyses were performed to explore potential effect modifiers. A total of 12,384 vaccinated children participated in screening for asthma and wheezing, 236 cases were screened, as well as 1445 controls were randomized. After adjusting for the covariates, childhood asthma and wheezing were significantly associated with cold exposure in the first trimester, with OR 1.731 (95% CI: 1.117-2.628), and cold exposure and heat exposure in the third trimester, with ORs 1.610 (95% CI: 1.030-2.473) and 2.039 (95% CI: 1.343-3.048). In the third trimester, enhanced impacts were found among girls, children whose distance of residence was close to the nearest main traffic road, and children whose parents have asthma. The study indicates that exposure to extreme AT during the first and third trimesters could increase the risk of childhood asthma and wheezing.
摘要：
这项研究的目的是探讨母亲在怀孕期间AT对儿童哮喘和喘息的影响，以及这种关联中的潜在效应修饰剂。于2018年12月至2019年3月在济南市实施横断面研究，调查18个月至3岁儿童哮喘和喘息的患病率。然后，我们进行了一项基于人群的病例对照研究,以探讨产前不同AT暴露水平与儿童哮喘和喘息之间的关系.通过广义加性模型和逻辑回归模型对关联进行评估，并进行了分层分析以探索潜在的效应修正剂。共有12384名接种疫苗的儿童参加了哮喘和喘息的筛查，筛查236例，以及1445名对照被随机分配.在调整协变量后，儿童哮喘和喘息与妊娠早期的冷暴露显著相关，OR为1.731（95%CI：1.117-2.628），妊娠晚期的冷暴露和热暴露，ORs为1.610（95%CI：1.030-2.473）和2.039（95%CI：1.343-3.048）。在妊娠晚期，在女孩中发现了增强的影响，居住距离最近的主要交通道路的儿童，和父母患有哮喘的孩子。研究表明，在妊娠早期和晚期暴露于极端AT可能会增加儿童哮喘和喘息的风险。
