Abstract：
BACKGROUND: Acute pain is a common symptom in children of all ages, and is associated with a variety of conditions. Despite the availability of guidelines, pain often remains underestimated and undertreated. Paracetamol and ibuprofen are the most commonly used drugs for analgesia in Pediatrics. Multimodal pain management by using a combination of paracetamol and ibuprofen results in greater analgesia.
METHODS: An investigation using the Nominal Group Technique was carried out between May and August 2022. Two open (non-anonymous) questionnaires were consecutively sent to a Board of ten clinicians to understand their opinions on the use of the oral paracetamol and ibuprofen association. Answers were examined in a final meeting where conclusions were drawn.
RESULTS: The board achieved a final consensus on a better analgesic power of paracetamol and ibuprofen in fixed-dose combination as compared to monotherapy, without compromising safety. Strong consensus was reached on the opinion that the fixed-dose combination of paracetamol and ibuprofen may be a useful option in case of inefficacy of one or other drug as monotherapy, especially in case of headaches, odontalgia, earache, and musculoskeletal pain. The use of the fixed combination may be also considered suitable for postoperative pain management.
CONCLUSIONS: The use of the fixed-dose combination may represent advantage in terms of efficacy and safety, allowing a better control of the dose of both paracetamol and ibuprofen as monotherapy, thus minimizing the risk of incorrect dosage. However, the limited evidence available highlights the need for future well designed studies to better define the advantages of this formulation in the various therapeutic areas.
METHODS: An investigation using the Nominal Group Technique was carried out between May and August 2022. Two open (non-anonymous) questionnaires were consecutively sent to a Board of ten clinicians to understand their opinions on the use of the oral paracetamol and ibuprofen association. Answers were examined in a final meeting where conclusions were drawn.
RESULTS: The board achieved a final consensus on a better analgesic power of paracetamol and ibuprofen in fixed-dose combination as compared to monotherapy, without compromising safety. Strong consensus was reached on the opinion that the fixed-dose combination of paracetamol and ibuprofen may be a useful option in case of inefficacy of one or other drug as monotherapy, especially in case of headaches, odontalgia, earache, and musculoskeletal pain. The use of the fixed combination may be also considered suitable for postoperative pain management.
CONCLUSIONS: The use of the fixed-dose combination may represent advantage in terms of efficacy and safety, allowing a better control of the dose of both paracetamol and ibuprofen as monotherapy, thus minimizing the risk of incorrect dosage. However, the limited evidence available highlights the need for future well designed studies to better define the advantages of this formulation in the various therapeutic areas.
摘要：
背景：急性疼痛是所有年龄段儿童的常见症状，并与各种条件有关。尽管有指南，疼痛往往被低估和治疗不足。扑热息痛和布洛芬是儿科最常用的镇痛药物。联合使用对乙酰氨基酚和布洛芬的多模式疼痛管理可获得更大的镇痛效果。
方法：在2022年5月至8月之间进行了使用标称分组技术的调查。连续向由十名临床医生组成的委员会发送了两份开放式（非匿名）问卷，以了解他们对口服扑热息痛和布洛芬协会使用的意见。在最后一次会议上审查了答案，并得出结论。
结果：委员会就扑热息痛和布洛芬在固定剂量组合中的镇痛力优于单一疗法达成了最终共识，不影响安全。在一种或其他药物作为单一疗法无效的情况下，对乙酰氨基酚和布洛芬的固定剂量组合可能是有用的选择，尤其是在头痛的情况下，牙本质,耳痛,肌肉骨骼疼痛.固定组合的使用也可以被认为适用于术后疼痛管理。
结论：使用固定剂量组合可能在疗效和安全性方面具有优势，允许更好地控制扑热息痛和布洛芬的剂量作为单一疗法，从而最大限度地减少不正确剂量的风险。然而,现有的有限证据突出表明,未来需要精心设计的研究,以更好地确定该制剂在各个治疗领域的优势.
方法：在2022年5月至8月之间进行了使用标称分组技术的调查。连续向由十名临床医生组成的委员会发送了两份开放式（非匿名）问卷，以了解他们对口服扑热息痛和布洛芬协会使用的意见。在最后一次会议上审查了答案，并得出结论。
结果：委员会就扑热息痛和布洛芬在固定剂量组合中的镇痛力优于单一疗法达成了最终共识，不影响安全。在一种或其他药物作为单一疗法无效的情况下，对乙酰氨基酚和布洛芬的固定剂量组合可能是有用的选择，尤其是在头痛的情况下，牙本质,耳痛,肌肉骨骼疼痛.固定组合的使用也可以被认为适用于术后疼痛管理。
结论：使用固定剂量组合可能在疗效和安全性方面具有优势，允许更好地控制扑热息痛和布洛芬的剂量作为单一疗法，从而最大限度地减少不正确剂量的风险。然而,现有的有限证据突出表明,未来需要精心设计的研究,以更好地确定该制剂在各个治疗领域的优势.
