Abstract：
Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies have been reported, in which almost all the HDFN-associated anti-M were warmly reacting. Here we report two cases of severe HDFN associated with cold-reacting IgG anti-M. In both cases, pregnancy was terminated, in weeks 33 and 23 respectively, due to a diagnosis of fetal growth retardation (FGR). To our knowledge, these are the most severe HDFN cases caused by cold-reacting IgG anti-M.
摘要：
已报道了几例由免疫球蛋白G（IgG）抗M抗体引起的胎儿和新生儿溶血病（HDFN）。几乎所有与HDFN相关的反M都反应热烈。在这里，我们报告了两例与冷反应IgG抗M相关的严重HDFN。在这两种情况下，怀孕终止了,分别在第33周和第23周，由于胎儿生长迟缓（FGR）的诊断。据我们所知,这些是由冷反应IgG抗M引起的最严重的HDFN病例。
