%0 Case Reports
%T Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus.
%A Liang YL
%A Shi Y
%A Su YQ
%A Wu F
%A Liang Y
%A Fan X
%A Lin J
%A Liu Y
%A Long P
%A Ren J
%A Liang S
%J Iran J Immunol
%V 20
%N 1
%D Mar 2023 14
%M 36934323
%F 1.206
%R 10.22034/iji.2023.93993.2273
%X Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies have been reported, in which almost all the HDFN-associated anti-M were warmly reacting. Here we report two cases of severe HDFN associated with cold-reacting IgG anti-M. In both cases, pregnancy was terminated, in weeks 33 and 23 respectively, due to a diagnosis of fetal growth retardation (FGR). To our knowledge, these are the most severe HDFN cases caused by cold-reacting IgG anti-M.