Abstract：
Rheumatoid arthritis is an autoimmune disorder characterized by swelling in synovial joints and erosion of bones. The disease is normally treated with conventional drugs which provide only temporary relief to the symptoms. Over the past few years, mesenchymal stromal cells have become the center of attention for treating this disease due to their immuno-modulatory and anti-inflammatory characteristics. Various studies on treatment of rheumatoid arthritis by using these cells have shown positive outcomes in terms of reduction in the level of pain as well as improvement of the function and structure of joints. Mesenchymal stromal cells can be derived from multiple sources, however, the ones derived from bone marrow are considered most beneficial for treating several disorders including rheumatoid arthritis on account of being safer and more effective. This review summarizes all the preclinical and clinical studies which were conducted over the last ten years for therapy of rheumatoid arthritis utilizing these cells. The literature was reviewed using the terms \"mesenchymal stem/stromal cells and rheumatoid arthritis\'\' and \"bone marrow derived mesenchymal stromal cells and therapy of rheumatoid arthritis\'\'. Data was extracted to enable the readers to have access to the most relevant information regarding advancement in therapeutic potential of these stromal cells. Additionally, this review will also help in fulfilling any gap in current knowledge of readers about the outcome of using these cells in animal models, cell line and in patients suffering from rheumatoid arthritis and other autoimmune disorders as well.
摘要：
类风湿性关节炎是一种自身免疫性疾病，其特征是滑膜关节肿胀和骨骼侵蚀。该疾病通常用常规药物治疗，这些药物只能暂时缓解症状。在过去的几年里，间充质基质细胞由于其免疫调节和抗炎特性而成为治疗该疾病的关注中心。通过使用这些细胞治疗类风湿性关节炎的各种研究已经显示出在疼痛水平降低以及关节功能和结构改善方面的积极结果。间充质基质细胞可以来自多种来源，然而,由于更安全，更有效，骨髓来源的那些被认为对治疗包括类风湿性关节炎在内的几种疾病最有益。这篇综述总结了过去十年中利用这些细胞治疗类风湿性关节炎的所有临床前和临床研究。使用术语“间充质干细胞/基质细胞和类风湿关节炎”和“骨髓来源的间充质基质细胞和类风湿关节炎的治疗”进行了文献综述。提取数据以使读者能够获得关于这些基质细胞的治疗潜力的进展的最相关信息。此外,这篇评论还将有助于满足读者对在动物模型中使用这些细胞的结果的当前知识的任何差距，细胞系以及患有类风湿性关节炎和其他自身免疫性疾病的患者。
