■长期病毒感染导致的肝损伤,酒精消费,自身免疫性衰退,等因素可导致肝纤维化逐渐发展。不幸的是,直到现在,目前尚无有效的肝纤维化治疗方法。间充质干细胞,作为一种有前途的肝纤维化新疗法,可以通过迁移到肝损伤部位和改变纤维化区域的微环境来减缓纤维化的进展。
■通过纳入迄今为止的所有相关研究,全面评估间充质干细胞治疗肝纤维化的功效,并探索临床翻译和治疗机制的注意事项。
■数据源包括PubMed,WebofScience,Embase,和Cochrane图书馆,并一直建造到2023年10月。提取每个研究结果指标的数据进行综合分析。
■总体荟萃分析表明,间充质干细胞显着改善了肝功能。此外,它抑制转化生长因子-β的表达水平[SMD=4.21,95%CI(3.02,5.40)],这反过来沉默肝星状细胞,并显着减少肝纤维化的面积[SMD=3.61,95%CI(1.41,5.81)]。
■几个结果指标表明间充质干细胞治疗肝纤维化相对可靠。在一定剂量范围内,治疗效果是细胞剂量依赖性的,但在更高的剂量下不会更有效。骨髓间充质干细胞治疗肝纤维化效果优于其他来源的间充质干细胞。
■标识符CRD42022354768。
UNASSIGNED: Liver damage due to long-term viral infection, alcohol consumption, autoimmune decline, and other factors could lead to the gradual development of liver fibrosis. Unfortunately, until now, there has been no effective treatment for liver fibrosis. Mesenchymal stem cells, as a promising new therapy for liver fibrosis, can slow the progression of fibrosis by migrating to the site of liver injury and by altering the microenvironment of the fibrotic area.
UNASSIGNED: By including all relevant studies to date to comprehensively assess the efficacy of mesenchymal stem cells for the treatment of hepatic fibrosis and to explore considerations for clinical translation and therapeutic mechanisms.
UNASSIGNED: Data sources included PubMed, Web of Science, Embase, and Cochrane Library, and were constructed until October 2023. Data for each study outcome indicator were extracted for comprehensive analysis.
UNASSIGNED: The overall meta-analysis showed that mesenchymal stem cells significantly improved liver function. Moreover, it inhibited the expression level of transforming growth factor-β [SMD = 4.21, 95% CI (3.02,5.40)], which in turn silenced hepatic stellate cells and significantly reduced the area of liver fibrosis [SMD = 3.61, 95% CI (1.41,5.81)].
UNASSIGNED: Several outcome indicators suggest that mesenchymal stem cells therapy is relatively reliable in the treatment of liver fibrosis. The therapeutic effect is cell dose-dependent over a range of doses, but not more effective at higher doses. Bone-marrow derived mesenchymal stem cells were more effective in treating liver fibrosis than mesenchymal stem cells from other sources.
UNASSIGNED: Identifier CRD42022354768.