开发两性霉素 B 和乳铁蛋白联合加载的 PLGA - PEG - PEI 纳米颗粒的热敏水凝胶 , 以潜在根除眼部真菌感染 : 体外 ,离体和体内研究。
关键词: A, aqueous phase AMP, Amphotericin-B ANOVA, Analysis of variance Amphotericin-B Atomic force microscopy (AFM) BCS, Biopharmaceutical Classification System BLF, Bovine Lactoferrin CD14, Cluster of differentiation 14 CK, Creatine kinase Candida albicans Confocal laser scanning microscopy (CLSM) DLS, dynamic light scattering DMSO, dimethyl sulfoxide DSC, Differential scanning calorimetry Draize test EDC, ethyl-3-(3-dimethyl aminopropyl) carbodiimide EE%, Entrapment efficiency FT-IR, Fourier transform infrared FT-IR, Fourier-transform infrared spectroscopy GRAS, Generally recognized as a safe HCE-2, human corneal epithelial cells J, steady-state flux Kp, permeability coefficient LPS, Lipopolysaccharide Lactoferrin MIC, minimum inhibitory concentration NCCLS, National Committee for Clinical Laboratory Standards NHS, N-hydroxysuccinimide NPs, nanoparticles Nanoparticles O, organic phase P188, Kolliphor®P188 P407, Poloxamer 407 PBS, Phosphate buffered saline solution PDI, Polydispersity index PEG, polyethylene glycol PEI, poly-ethylene imine PLGA, Poly (lactic-co-glycolic acid) PS, Particle size Q24, amount penetrated after 24 h QR, Quantity retained REC, rules of the Study Ethics Committee SD, Standard deviations SE, Standard error SEM, Scanning electron microscope TEM, Transmission electron microscopy Triblock polymers PLGA-PEG-PEI ZP, Zeta potential.
来 源:
DOI:10.1016/j.ijpx.2023.100174
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