Abstract：
BACKGROUND: Maintenance intravenous fluids are frequently used in hospitalised pediatric patients. The aim of the study was to describe the adverse effects of isotonic fluid therapy in hospitalised patients, and its prevalence based on the rate of infusion.
METHODS: A prospective clinical observational study was designed. We included hospitalised patients between 3 months-old and 15-years-old were included with 0,9% isotonic solutions with 5% glucose within the first 24 h of administration. They were divided into two groups, depending on the quantity of liquid they received (restricted <100% vs 100% maintenance needs). Clinical data and laboratory findings were recorded in two different times (T0 when they were admitted to hospital and T1 within the first 24 h of administration).
RESULTS: The study included 84 patients, 33 received <100% maintenance needs and 51 patients received around 100%. The main adverse effects notified in the first 24 h of administration were hyperchloremia >110 mEq/L (16.6%) and oedema (19%). Oedema was more frequent in patients with lower age (p < 0,01). The hyperchloremia at 24 h of intravenous fluids was an independent risk factor of developing oedema (OR 1,73 (1,0-3,8), p = 0,06).
CONCLUSIONS: The use of isotonic fluids is not free from adverse effects, probably related to the rate of infusion and more likely to appear in infants. It`s necessary more studies that review the correct estimation of intravenous fluid needs in hospitalized children.
METHODS: A prospective clinical observational study was designed. We included hospitalised patients between 3 months-old and 15-years-old were included with 0,9% isotonic solutions with 5% glucose within the first 24 h of administration. They were divided into two groups, depending on the quantity of liquid they received (restricted <100% vs 100% maintenance needs). Clinical data and laboratory findings were recorded in two different times (T0 when they were admitted to hospital and T1 within the first 24 h of administration).
RESULTS: The study included 84 patients, 33 received <100% maintenance needs and 51 patients received around 100%. The main adverse effects notified in the first 24 h of administration were hyperchloremia >110 mEq/L (16.6%) and oedema (19%). Oedema was more frequent in patients with lower age (p < 0,01). The hyperchloremia at 24 h of intravenous fluids was an independent risk factor of developing oedema (OR 1,73 (1,0-3,8), p = 0,06).
CONCLUSIONS: The use of isotonic fluids is not free from adverse effects, probably related to the rate of infusion and more likely to appear in infants. It`s necessary more studies that review the correct estimation of intravenous fluid needs in hospitalized children.
摘要：
背景：儿科住院患者经常使用维持静脉输液。这项研究的目的是描述等渗液体治疗对住院患者的不利影响，以及基于输注率的患病率。
方法：设计了一项前瞻性临床观察性研究。我们包括3个月至15岁的住院患者，在给药的前24小时内，包括0,9％等渗溶液和5％葡萄糖。他们被分成两组,取决于他们接收的液体量(限制<100%vs100%维护需求)。在两个不同的时间记录临床数据和实验室检查结果（入院时的T0和给药的前24小时内的T1）。
结果：该研究包括84名患者，33名患者接受了<100%的维护需求，51名患者接受了约100%的维护需求。在给药前24小时通知的主要不良反应是高氯血症>110mEq/L（16.6％）和水肿（19％）。水肿在年龄较低的患者中更为常见（p<0.01）。静脉输液24h高氯血症是发生水肿的独立危险因素(OR1,73(1,0-3,8),p=0,06)。
结论：使用等渗液并非没有副作用，可能与输液率有关，更有可能出现在婴儿身上。有必要进行更多的研究，以审查对住院儿童静脉输液需求的正确估计。
方法：设计了一项前瞻性临床观察性研究。我们包括3个月至15岁的住院患者，在给药的前24小时内，包括0,9％等渗溶液和5％葡萄糖。他们被分成两组,取决于他们接收的液体量(限制<100%vs100%维护需求)。在两个不同的时间记录临床数据和实验室检查结果（入院时的T0和给药的前24小时内的T1）。
结果：该研究包括84名患者，33名患者接受了<100%的维护需求，51名患者接受了约100%的维护需求。在给药前24小时通知的主要不良反应是高氯血症>110mEq/L（16.6％）和水肿（19％）。水肿在年龄较低的患者中更为常见（p<0.01）。静脉输液24h高氯血症是发生水肿的独立危险因素(OR1,73(1,0-3,8),p=0,06)。
结论：使用等渗液并非没有副作用，可能与输液率有关，更有可能出现在婴儿身上。有必要进行更多的研究，以审查对住院儿童静脉输液需求的正确估计。
