METHODS: A prospective clinical observational study was designed. We included hospitalised patients between 3 months-old and 15-years-old were included with 0,9% isotonic solutions with 5% glucose within the first 24 h of administration. They were divided into two groups, depending on the quantity of liquid they received (restricted <100% vs 100% maintenance needs). Clinical data and laboratory findings were recorded in two different times (T0 when they were admitted to hospital and T1 within the first 24 h of administration).
RESULTS: The study included 84 patients, 33 received <100% maintenance needs and 51 patients received around 100%. The main adverse effects notified in the first 24 h of administration were hyperchloremia >110 mEq/L (16.6%) and oedema (19%). Oedema was more frequent in patients with lower age (p < 0,01). The hyperchloremia at 24 h of intravenous fluids was an independent risk factor of developing oedema (OR 1,73 (1,0-3,8), p = 0,06).
CONCLUSIONS: The use of isotonic fluids is not free from adverse effects, probably related to the rate of infusion and more likely to appear in infants. It`s necessary more studies that review the correct estimation of intravenous fluid needs in hospitalized children.
方法:设计了一项前瞻性临床观察性研究。我们包括3个月至15岁的住院患者,在给药的前24小时内,包括0,9%等渗溶液和5%葡萄糖。他们被分成两组,取决于他们接收的液体量(限制<100%vs100%维护需求)。在两个不同的时间记录临床数据和实验室检查结果(入院时的T0和给药的前24小时内的T1)。
结果:该研究包括84名患者,33名患者接受了<100%的维护需求,51名患者接受了约100%的维护需求。在给药前24小时通知的主要不良反应是高氯血症>110mEq/L(16.6%)和水肿(19%)。水肿在年龄较低的患者中更为常见(p<0.01)。静脉输液24h高氯血症是发生水肿的独立危险因素(OR1,73(1,0-3,8),p=0,06)。
结论:使用等渗液并非没有副作用,可能与输液率有关,更有可能出现在婴儿身上。有必要进行更多的研究,以审查对住院儿童静脉输液需求的正确估计。