Abstract：
Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α-amylase and α-glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A-E (1-5), were obtained by bioassay-guided isolation coupled with HPLC-QTOF-MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α-amylase and α-glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α-amylase (IC50 =17.5 μM) and α-glucosidase (IC50 =13.6 μM).
摘要：
豆荚菜在我国分布广泛。其分支提取物显示出潜在的α-淀粉酶和α-葡萄糖苷酶抑制活性。为了发现新的生物活性成分，五种未描述的酚苷，viburozosidesA-E（1-5），通过结合HPLC-QTOF-MS/MS分析的生物测定指导分离获得。通过光谱分析阐明了它们的结构，包括1DNMR，2DNMR,ECD,ORD。测试所有化合物的α-淀粉酶和α-葡糖苷酶抑制效力。化合物1显示出对α-淀粉酶(IC50=17.5μM)和α-葡糖苷酶(IC50=13.6μM)的显著竞争性抑制。
