{Reference Type}: Journal Article
{Title}: Five New Phenolic Glycosides from Viburnum luzonicum.
{Author}: Chen J;Zhao M;Zhou H;Tang Y;Ji W;Shao J;Zhao C;Zhao C;
{Journal}: Chem Biodivers
{Volume}: 20
{Issue}: 4
{Year}: Apr 2023 10
{Factor}: 2.745
{DOI}: 10.1002/cbdv.202300246
{Abstract}: Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α-amylase and α-glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A-E (1-5), were obtained by bioassay-guided isolation coupled with HPLC-QTOF-MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α-amylase and α-glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α-amylase (IC50 =17.5 μM) and α-glucosidase (IC50 =13.6 μM).