%0 Journal Article
%T Five New Phenolic Glycosides from Viburnum luzonicum.
%A Chen J
%A Zhao M
%A Zhou H
%A Tang Y
%A Ji W
%A Shao J
%A Zhao C
%A Zhao C
%J Chem Biodivers
%V 20
%N 4
%D Apr 2023 10
%M 36896855
%F 2.745
%R 10.1002/cbdv.202300246
%X Viburnum luzonicum is widely distributed in China. Its branch extracts showed potential α-amylase and α-glucosidase inhibitory activities. In order to discover new bioactive constituents, five undescribed phenolic glycosides, viburozosides A-E (1-5), were obtained by bioassay-guided isolation coupled with HPLC-QTOF-MS/MS analysis. Their structures were elucidated by spectroscopic analyses, including 1D NMR, 2D NMR, ECD, and ORD. All compounds were tested for their α-amylase and α-glucosidase inhibitory potency. Compound 1 showed significantly competitive inhibition against α-amylase (IC50 =17.5 μM) and α-glucosidase (IC50 =13.6 μM).