Abstract：
As the global population ages, bone-related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, have been used to treat bone-related diseases due to their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, the modified exosomes exhibit strong bone-targeting capabilities that may improve efficacy and avoid systemic side effects, demonstrating promising translational potential. However, a review of bone-targeted exosomes is still lacking. Thus, the recently developed exosomes for bone-targeting applications in this review are focused. The biogenesis and bone-targeting regulatory functions of exosomes, the constructive strategies of modified exosomes to improve bone-targeting, and their therapeutic effects for bone-related diseases are introduced. By summarizing developments and challenges in bone-targeted exosomes, It is striven to shed light on the selection of exosome constructive strategies for different bone diseases and highlight their translational potential for future clinical orthopedics.
摘要：
随着全球人口老龄化,骨相关疾病日益成为威胁人类健康的重大社会问题。外泌体,作为天然细胞产物，由于其优越的生物相容性，已被用于治疗骨相关疾病，生物屏障渗透，和治疗效果。此外，修饰的外泌体表现出强大的骨靶向能力，可以提高疗效并避免全身副作用，展示了有希望的翻译潜力。然而,目前仍缺乏对骨靶向外泌体的综述.因此，在这篇综述中,我们重点关注最近开发的用于骨靶向应用的外泌体.我们介绍了外泌体的生物发生和骨靶向调节功能，改良外泌体改善骨靶向的建设性策略，以及它们对骨骼相关疾病的治疗效果。通过总结骨靶向外泌体的发展和挑战，我们努力阐明针对不同骨骼疾病的外泌体建设性策略的选择，并强调其对未来临床骨科的转化潜力。本文受版权保护。保留所有权利。
