关键词: brain atrophy clinicopathological associations hemispheric dominance nonfluent variant primary progressive aphasia primary progressive apraxia of speech

Mesh : Humans Aphasia, Primary Progressive / diagnosis Brain / pathology Speech Diagnosis, Differential Apraxias / diagnosis

来  源:   DOI:10.1111/ene.15766

Abstract:
In this issue of European Journal of Neurology, Robinson et al. present a novel study on primary progressive apraxia of speech. The authors describe different clinicopathological profiles in patients with left-dominant, right-dominant, and bilateral atrophy of the supplementary motor area and lateral premotor cortex. This commentary discusses the importance of this evidence for understanding individual differences among these patients, distinguishing them from those with nonfluent variant primary progressive aphasia, and analyzing the relations between motor speech deficits and underlying pathology.
摘要:
在本期欧洲神经病学杂志上,罗宾逊等人。提出了一项关于原发性进行性言语失用症的新研究。作者描述了左优势患者的不同临床病理特征,右翼主导,补充运动区和外侧运动前皮层的双侧萎缩。这篇评论讨论了这些证据对理解这些患者之间个体差异的重要性,区别于那些非流利的原发性进行性失语症,并反思运动言语缺陷与基础病理之间的关系。
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