背景:语义认知既需要语义表示(概念知识),和语义控制(为特定上下文/任务塑造和操纵信息的能力)(LambonRalph,Jefferies,帕特森,&罗杰斯,2017)。先前的研究将语义痴呆的语义表征损失与中风后语义失语症(SA)的语义控制缺陷进行了对比(Jefferies&LambonRalph,2006年;汤普森等人。,2022年)。原发性进行性失语症(lvPPA)的logopenic变体与SA具有神经解剖学共性,包括以左颞顶和下额叶区域为中心的损伤,和神经心理学的共性,包括执行和语言障碍。因此,我们调查了lvPPA是否会损害语义控制。
方法:我们比较了12名患有lvPPA的个体,9患有典型的遗忘型阿尔茨海默病(AD),和12个年龄匹配的健康对照在一系列的语言和非语言语义,语言,记忆和执行功能测试。
结果:lvPPA患者在不同的测试中跨越了多个水平的表现,并表现出语义控制缺陷的特征:(i)他们在需要更大语义需求的测试中表现出损害(例如,语义关联知识测试比简单的单词-图片匹配更多);(ii)只有lvPPA患者在语义和执行测试之间表现出很强的相关性;(iii)在lvPPA患者中未发现项目熟悉度的影响;(iv)lvPPA和AD患者均受益于波士顿命名测试中的语音提示。
结论:LvPPA患者在语义测试方面的表现与先前报道的SA相似,提示语义控制受损。成像分析正在进行中,将在AAIC会议上提供。参考资料:Jefferies,E.,&LambonRalph,M.A.(2006年)。卒中失语症与语义痴呆的语义损害:病例系列比较。大脑,129(Pt8),2132-2147。https://doi.org/10.1093/brain/awl153LambonRalph,M.A.,Jefferies,E.,帕特森,K.,&罗杰斯,T、T、(2017年)。语义认知的神经和计算基础。NatRevNeurosci,18(1)、42-55.https://doi.org/10.1038/nrn.2016.150Thompson,H.E.,Noonan,K.A.,Halai,A.D.,霍夫曼,P.,Stampacchia,S、Hallam,G.,...Jefferies,E、(2022年)。对颞顶皮层的损害足以使语义控制受损。皮质,156,71-85。https://doi.org/10.1016/j.cortex.2022.05.022。
BACKGROUND: Semantic cognition requires both semantic representation (conceptual knowledge), and semantic control (the ability to shape and manipulate information for a particular context/task) (Lambon Ralph, Jefferies, Patterson, & Rogers, 2017). Prior investigations have contrasted the semantic representation loss in semantic dementia with semantic control deficits in post-stroke semantic aphasia (SA) (Jefferies & Lambon Ralph, 2006; Thompson et al., 2022). The logopenic variant of primary progressive aphasia (lvPPA) has neuroanatomical commonalities with SA, including damage centred on the left temporoparietal and inferior frontal regions, and neuropsychological commonalities including executive and language impairments. Accordingly, we investigated whether lvPPA impairs semantic control.
METHODS: We compared 12 individuals with lvPPA, 9 with typical amnestic Alzheimer\'s disease (AD), and 12 age-matched healthy controls on a battery of verbal and non-verbal semantic, language, memory and executive functioning tests.
RESULTS: The lvPPA patients spanned multiple levels of performance across the different tests and showed the characteristic features of a semantic control deficit: (i) They showed impairments in tests that require greater semantic demand (e.g., semantic association knowledge test more than straightforward word-picture matching); (ii) only lvPPA patients showed strong correlations between semantic and executive tests; (iii) an effect of item familiarity was not found in lvPPA patients; and (iv) both lvPPA and AD patients benefited from phonemic cueing on the Boston Naming Test.
CONCLUSIONS: LvPPA patients\' performance on semantic tests is similar to that of previously reported SA, suggesting an impairment of semantic control. Imaging analysis is underway and will be available at the AAIC conference. References: Jefferies, E., & Lambon Ralph, M. A. (2006). Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain, 129(Pt 8), 2132-2147. https://doi.org/10.1093/brain/awl153 Lambon Ralph, M. A., Jefferies, E., Patterson, K., & Rogers, T. T. (2017). The neural and computational bases of semantic cognition. Nat Rev Neurosci, 18(1), 42-55. https://doi.org/10.1038/nrn.2016.150 Thompson, H. E., Noonan, K. A., Halai, A. D., Hoffman, P., Stampacchia, S., Hallam, G., . . . Jefferies, E. (2022). Damage to temporoparietal cortex is sufficient for impaired semantic control. Cortex, 156, 71-85. https://doi.org/10.1016/j.cortex.2022.05.022.