Abstract：
Cognitive processing relies on the functional coupling between the cerebrum and cerebellum. However, it remains unclear how the 2 collaborate in amnestic mild cognitive impairment (aMCI) patients. With functional magnetic resonance imaging techniques, we compared cerebrocerebellar functional connectivity during the resting state (rsFC) between the aMCI and healthy control (HC) groups. Additionally, we distinguished coupling between functionally corresponding and noncorresponding areas across the cerebrum and cerebellum. The results demonstrated decreased rsFC between both functionally corresponding and noncorresponding areas, suggesting distributed deficits of cerebrocerebellar connections in aMCI patients. Increased rsFC was also observed, which were between functionally noncorresponding areas. Moreover, the increased rsFC was positively correlated with attentional scores in the aMCI group, and this effect was absent in the HC group, supporting that there exists a compensatory mechanism in patients. The current study contributes to illustrating how the cerebellum adjusts its coupling with the cerebrum in individuals with cognitive impairment.
摘要：
认知过程依赖于大脑和小脑之间的功能耦合。然而,目前尚不清楚2在遗忘型轻度认知障碍(aMCI)患者中如何协作.用功能磁共振成像技术，我们比较了aMCI组和健康对照组(HC)在静息状态(rsFC)下的脑小脑功能连接.此外,我们区分了大脑和小脑功能对应和非对应区域之间的耦合。结果表明，功能对应和非对应区域之间的rsFC下降，提示aMCI患者脑小脑连接的分布缺陷。还观察到rsFC增加，它们在功能上不对应的区域之间。此外，aMCI组rsFC升高与注意评分呈正相关,这种效应在HC组中不存在，支持患者存在代偿机制。当前的研究有助于说明小脑如何调整其与认知障碍患者的大脑耦合。
