Abstract：
We report the case of a 59-year-old female patient, presenting with pustular rash on both hands and pain in the lumbosacral part and left lower limb. A magnetic resonance imaging examination of the left leg was undertaken and the result showed that a malignant lesion with bone destruction of the left femoral shaft could not be excluded. Subsequently, bone tumor was excluded by pathological examination. Lung computed tomography scan showed patchy consolidation and cord shadow in the middle left lung. Subsequently, lung cancer was excluded by pathological examination, and the histopathological changes of lung were consistent with those of organized pneumonia. Blood tests revealed elevated C-reactive protein and erythrocyte sedimentation rate. Antinuclear antibody, rheumatoid factor, and human leukocyte antigen-B27 were unremarkable. Whole body bone scintigraphy via technetium 99m-methyl diphosphonate showed increased radionuclide uptake in the left middle femur. Based on her clinical manifestations, imaging results and bone scintigraphy, the patient was diagnosed as having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. Loxoprofen and Tripterygium wilfordii Hook F led to impressive clinical and radiologic improvement.
摘要：
我们报道了一个59岁的女性患者，双手出现脓疱疹，腰骶部和左下肢疼痛。对左腿进行了磁共振成像检查，结果表明不能排除具有左股骨干骨破坏的恶性病变。随后，病理检查排除骨肿瘤。肺部计算机断层扫描显示左中肺斑片样实变和脊髓阴影。随后，病理检查排除肺癌,肺组织病理学改变与组织性肺炎一致。血液检查显示C反应蛋白和红细胞沉降率升高。抗核抗体,类风湿因子,人类白细胞抗原-B27不显著。通过99m-甲基二膦酸盐的全身骨闪烁显像显示，左股骨中部的放射性核素摄取增加。根据她的临床表现，成像结果和骨闪烁显像，病人被诊断为滑膜炎,痤疮,脓疱病,骨增生,骨炎（SAPHO）综合征。洛索洛芬和雷公藤HookF导致了令人印象深刻的临床和放射学改善。
