Abstract：
Four new compounds (1-4), together with 23 known compounds (5-27), were isolated from the whole plant of Taraxacum mongolicum. Among them, one racemic mixture (4) was separated with a chiral HPLC column. Their structures were identified by spectroscopic evidence and mass spectrometry. The absolute configurations of compounds 1, 3, and 4 were determined via comparison of their calculated and experimental electronic circular dichroism (ECD) spectra. Compound 3 showed an inhibitory effect against aldose reductase with a 59.1% inhibition. Two known compounds (13 and 27) showed α-glucosidase inhibition of 51.5% and 56.0%, respectively.
摘要：
四个新化合物（1-4），连同23种已知化合物(5-27)，从蒲公英全株中分离得到。其中,用手性HPLC柱分离一种外消旋混合物(4)。通过光谱证据和质谱鉴定了它们的结构。化合物1、3和4的绝对构型通过它们的计算和实验电子圆二色性(ECD)光谱的比较来确定。化合物3显示对醛糖还原酶的抑制作用,抑制率为59.1%。两种已知化合物(13和27)对α-葡萄糖苷酶的抑制作用分别为51.5%和56.0%,分别。
