Abstract：
OBJECTIVE: Psychological distress is considered a factor for cancer development. However, the impact of mood disorders (depression and bipolar) on the development of cervical cancer remains uncertain. We conducted a nationwide population-based retrospective cohort study to investigate the association between mood disorders and the subsequent risk of developing cervical cancer.
METHODS: A total of 138,130 participants\' profiles between 2000 and 2012 were extracted from the National Health Insurance Research Database and subdivided into a mood-disorder cohort (27,626 participants) and a non-mood-disorder cohort (110,504 participants). Cohorts were propensity-matched for a 1:4 ratio according to age and index year. The Cox proportional hazards regression model was utilized for assessing cervical cancer risk between cohorts.
RESULTS: Kaplan-Meier analysis revealed that the mood-disorder cohort had a higher cumulative incidence of cervical cancer. The mood-disorder cohort was also associated with an increased risk of cervical cancer after adjustments for potential confounders. Subgroup analysis revealed a negative impact of mood disorders on cervical cancer, especially in the 30-50 years and white-collar groups.
CONCLUSIONS: Our findings demonstrated that mood disorders were associated with an increased risk of cervical cancer development, which provide helpful information for clinical strategies to reduce the incidence of cervical cancer in this vulnerable population.
METHODS: A total of 138,130 participants\' profiles between 2000 and 2012 were extracted from the National Health Insurance Research Database and subdivided into a mood-disorder cohort (27,626 participants) and a non-mood-disorder cohort (110,504 participants). Cohorts were propensity-matched for a 1:4 ratio according to age and index year. The Cox proportional hazards regression model was utilized for assessing cervical cancer risk between cohorts.
RESULTS: Kaplan-Meier analysis revealed that the mood-disorder cohort had a higher cumulative incidence of cervical cancer. The mood-disorder cohort was also associated with an increased risk of cervical cancer after adjustments for potential confounders. Subgroup analysis revealed a negative impact of mood disorders on cervical cancer, especially in the 30-50 years and white-collar groups.
CONCLUSIONS: Our findings demonstrated that mood disorders were associated with an increased risk of cervical cancer development, which provide helpful information for clinical strategies to reduce the incidence of cervical cancer in this vulnerable population.
摘要：
目的：心理困扰被认为是癌症发展的一个因素。然而,情绪障碍（抑郁和双相情感障碍）对宫颈癌发展的影响仍然不确定。我们进行了一项全国性的基于人群的回顾性队列研究，以调查情绪障碍与随后发生宫颈癌的风险之间的关系。
方法：从国家健康保险研究数据库中提取了2000年至2012年的138,130名参与者，并细分为情绪障碍队列（27,626名参与者）和非情绪障碍队列（110,504名参与者）。根据年龄和指数年份，队列的倾向匹配比例为1：4。Cox比例风险回归模型用于评估队列之间的宫颈癌风险。
结果：Kaplan-Meier分析显示，情绪障碍队列中宫颈癌的累积发病率较高。调整潜在的混杂因素后，情绪障碍队列也与宫颈癌风险增加相关。亚组分析显示情绪障碍对宫颈癌有负面影响，尤其是在30-50年代和白领阶层。
结论：我们的研究结果表明，情绪障碍与宫颈癌发展的风险增加有关。这为降低这一脆弱人群宫颈癌发病率的临床策略提供了有益的信息。
方法：从国家健康保险研究数据库中提取了2000年至2012年的138,130名参与者，并细分为情绪障碍队列（27,626名参与者）和非情绪障碍队列（110,504名参与者）。
结果：Kaplan-Meier分析显示，情绪障碍队列中宫颈癌的累积发病率较高。
结论：我们的研究结果表明，情绪障碍与宫颈癌发展的风险增加有关。
