METHODS: A total of 138,130 participants\' profiles between 2000 and 2012 were extracted from the National Health Insurance Research Database and subdivided into a mood-disorder cohort (27,626 participants) and a non-mood-disorder cohort (110,504 participants). Cohorts were propensity-matched for a 1:4 ratio according to age and index year. The Cox proportional hazards regression model was utilized for assessing cervical cancer risk between cohorts.
RESULTS: Kaplan-Meier analysis revealed that the mood-disorder cohort had a higher cumulative incidence of cervical cancer. The mood-disorder cohort was also associated with an increased risk of cervical cancer after adjustments for potential confounders. Subgroup analysis revealed a negative impact of mood disorders on cervical cancer, especially in the 30-50 years and white-collar groups.
CONCLUSIONS: Our findings demonstrated that mood disorders were associated with an increased risk of cervical cancer development, which provide helpful information for clinical strategies to reduce the incidence of cervical cancer in this vulnerable population.
方法:从国家健康保险研究数据库中提取了2000年至2012年的138,130名参与者,并细分为情绪障碍队列(27,626名参与者)和非情绪障碍队列(110,504名参与者)。
结果:Kaplan-Meier分析显示,情绪障碍队列中宫颈癌的累积发病率较高。
结论:我们的研究结果表明,情绪障碍与宫颈癌发展的风险增加有关。