在优勤劳动中,自主神经系统由副交感神经系统主导,确保子宫和胎盘的最佳血流量。这项研究的重点是检测在妊娠子宫的子宫内口(IUO)和子宫下段(LUS)中儿茶酚胺(C)神经纤维的定量存在,可以在劳动和分娩中发挥作用。在接受预定的剖宫产术(CS)之前,共有102名妇女入选;患者在分娩外表现为单胎胎儿。在CS期间,外科医生在LUS上采样了两个连续的5mm深的全厚度切片(包括子宫肌层),并从子宫颈IUO处随机选择了两个5mm深的样本。研究所有组织学样品以量化A神经纤维的分布。作者证明IUO中的A纤维浓度(46±4.8)明显高于LUS中的A纤维浓度(21±2.6),表明妊娠子宫颈的A神经纤维浓度高于足月LUS。孕妇的机械敏感起搏器在身体处于生理状态时可以正常工作,允许正常的子宫收缩和正常分娩。宫颈C神经纤维频率的增加可能会影响平滑肌细胞束的激活,这可能会导致异常的机械敏感性起搏器激活-停用循环。紧张的情况(焦虑,紧张,胎儿头部位置)使交感神经系统变得更加活跃,通过妊娠子宫颈的这些神经纤维工作。它们可能会干扰机械敏感起搏器,减缓子宫收缩和子宫颈成熟,这可能会导致分娩困难。
In eutocic labor, the autonomic nervous system is dominated by the parasympathetic system, which ensures optimal blood flow to the uterus and placenta. This study is focused on the detection of the quantitative presence of catecholamine (C) neurofibers in the internal uterine orifice (IUO) and in the lower uterine segment (LUS) of the pregnant uterus, which could play a role in labor and delivery. A total of 102 women were enrolled before their submission to a scheduled cesarean section (CS); patients showed a singleton fetus in a cephalic presentation outside labor. During CS, surgeons sampled two serial consecutive full-thickness sections 5 mm in depth (including the myometrial layer) on the LUS and two randomly selected samples of 5 mm depth from the IUO of the
cervix. All histological samples were studied to quantify the distribution of A nerve fibers. The authors demonstrated a significant and notably higher concentration of A fibers in the IUO (46 ± 4.8) than in the LUS (21 ± 2.6), showing that the pregnant
cervix has a greater concentration of A neurofibers than the at-term LUS. Pregnant women\'s mechanosensitive pacemakers can operate normally when the body is in a physiological state, which permits normal uterine contractions and eutocic delivery. The increased frequency of C neurofibers in the
cervix may influence the smooth muscle cell bundles\' activation, which could cause an aberrant mechano-sensitive pacemaker activation-deactivation cycle. Stressful circumstances (anxiety, tension, fetal head position) cause the sympathetic nervous system to become more active, working through these nerve fibers in the gravid
cervix. They might interfere with the mechano-sensitive pacemakers, slowing down the uterine contractions and
cervix ripening, which could result in dystocic labor.