PDF(Pubmed)
Abstract：
In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.
摘要：
在动脉粥样硬化中，局部患病区域的慢性炎症过程可能导致活性氧（ROS）的积累。在这项研究中,我们设计了一种高灵敏的H2O2清除纳米仿生系统，负载普罗布考（RPP-PU），更有效地治疗动脉粥样硬化.RPP材料对H2O2具有较高的敏感性,反应灵敏度可从40μmol/L降至10μmol/L,接近病理环境中H2O2的最低浓度水平。RPP-PU延缓了PU的释放并延长了其在体内的持续时间。在载脂蛋白E缺陷（ApoE-/-）小鼠中，RPP-PU有效消除病理性ROS，降低脂质和相关代谢酶的水平，并显著减少血管斑块和纤维的面积。我们的研究表明，清除H2O2的纳米仿生系统可以清除动脉粥样硬化病变中丰富的ROS，从而减少用于治疗动脉粥样硬化的氧化应激,并因此更理想地实现动脉粥样硬化的治疗目标。
