%0 Journal Article
%T Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis.
%A Liang X
%A Li H
%A Li X
%A Tian X
%A Zhang A
%A Luo Q
%A Duan J
%A Chen Y
%A Pang L
%A Li C
%A Liang XJ
%A Zeng Y
%A Yang J
%J Acta Pharm Sin B
%V 13
%N 1
%D Jan 2023
%M 36815039
%F 14.903
%R 10.1016/j.apsb.2022.04.002
%X In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.