{Reference Type}: Journal Article
{Title}: Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis.
{Author}: Liang X;Li H;Li X;Tian X;Zhang A;Luo Q;Duan J;Chen Y;Pang L;Li C;Liang XJ;Zeng Y;Yang J;
{Journal}: Acta Pharm Sin B
{Volume}: 13
{Issue}: 1
{Year}: Jan 2023
{Factor}: 14.903
{DOI}: 10.1016/j.apsb.2022.04.002
{Abstract}: In atherosclerosis, chronic inflammatory processes in local diseased areas may lead to the accumulation of reactive oxygen species (ROS). In this study, we devised a highly sensitive H2O2-scavenging nano-bionic system loaded with probucol (RPP-PU), to treat atherosclerosis more effectively. The RPP material had high sensitivity to H2O2, and the response sensitivity could be reduced from 40 to 10 μmol/L which was close to the lowest concentration of H2O2 levels of the pathological environment. RPP-PU delayed the release and prolonged the duration of PU in vivo. In Apolipoprotein E deficient (ApoE‒/‒) mice, RPP-PU effectively eliminated pathological ROS, reduced the level of lipids and related metabolic enzymes, and significantly decreased the area of vascular plaques and fibers. Our study demonstrated that the H2O2-scavenging nano-bionic system could scavenge the abundant ROS in the atherosclerosis lesion, thereby reducing the oxidative stress for treating atherosclerosis and thus achieve the therapeutic goals with atherosclerosis more desirably.