PDF(Pubmed)
Abstract：
After three years with no confirmed cholera cases in Haiti, an outbreak of Vibrio cholerae O1 emerged in October 2022. Levels of pre-existing antibodies provide an estimate of prior immunologic exposure, reveal potentially relevant immune responses, and set a baseline for future serosurveillance. We analyzed dried blood spots collected in 2021 from a population-weighted representative cross-sectional serosurvey in two communes in the Ouest Department of Haiti. We found lower levels of circulating IgG and IgA antibodies against V. cholerae lipopolysaccharide (LPS, IgG and IgA p<0.0001) in those below 5 years of age compared to those five years and older. Among a subset of patients with higher titers of antibodies, we were unable to detect any functional (vibriocidal) antibodies. In conclusion, the lack of detectable functional antibodies, and age-discordant levels of V. cholerae LPS IgG, suggest that populations in Haiti may be highly susceptible to cholera disease, especially among young children.
摘要：
在海地没有确诊霍乱病例三年后，2022年10月爆发霍乱弧菌O1。预先存在的抗体水平提供了对先前免疫暴露的估计，揭示潜在相关的免疫反应，并为未来的血清监测设定基线。我们分析了2021年从海地Ouest省两个社区的人口加权代表性横断面血清调查中收集的干血点。我们发现针对霍乱弧菌脂多糖的循环IgG和IgA抗体水平较低（LPS，与5岁及以上的人群相比，5岁以下的人群中的IgG和IgAp<0.0001）。在抗体滴度较高的患者中，我们无法检测到任何功能性（杀弧菌）抗体。总之,缺乏可检测的功能性抗体，和年龄不一致的霍乱弧菌LPSIgG水平，表明海地的人口可能高度易患霍乱病，尤其是在年幼的孩子中。
