%0 Preprint
%T A population-based serological survey of Vibrio cholerae antibody titers in Ouest Department, Haiti in the year prior to the 2022 cholera outbreak.
%A Clutter CH
%A Klarman MB
%A Cajusma Y
%A Cato ET
%A Sayeed A
%A Brinkley L
%A Jensen O
%A Baril C
%A De Rochars VMB
%A Azman AS
%A Long MT
%A Cummings D
%A Leung DT
%A Nelson EJ
%J medRxiv
%V 0
%N 0
%D Feb 2023 8
%M 36798289
暂无%R 10.1101/2023.02.06.23285537
%X After three years with no confirmed cholera cases in Haiti, an outbreak of Vibrio cholerae O1 emerged in October 2022. Levels of pre-existing antibodies provide an estimate of prior immunologic exposure, reveal potentially relevant immune responses, and set a baseline for future serosurveillance. We analyzed dried blood spots collected in 2021 from a population-weighted representative cross-sectional serosurvey in two communes in the Ouest Department of Haiti. We found lower levels of circulating IgG and IgA antibodies against V. cholerae lipopolysaccharide (LPS, IgG and IgA p<0.0001) in those below 5 years of age compared to those five years and older. Among a subset of patients with higher titers of antibodies, we were unable to detect any functional (vibriocidal) antibodies. In conclusion, the lack of detectable functional antibodies, and age-discordant levels of V. cholerae LPS IgG, suggest that populations in Haiti may be highly susceptible to cholera disease, especially among young children.