{Reference Type}: Preprint
{Title}: A population-based serological survey of Vibrio cholerae antibody titers in Ouest Department, Haiti in the year prior to the 2022 cholera outbreak.
{Author}: Clutter CH;Klarman MB;Cajusma Y;Cato ET;Sayeed A;Brinkley L;Jensen O;Baril C;De Rochars VMB;Azman AS;Long MT;Cummings D;Leung DT;Nelson EJ;
{Journal}: medRxiv
{Volume}: 0
{Issue}: 0
{Year}: Feb 2023 8
暂无{DOI}: 10.1101/2023.02.06.23285537
{Abstract}: After three years with no confirmed cholera cases in Haiti, an outbreak of Vibrio cholerae O1 emerged in October 2022. Levels of pre-existing antibodies provide an estimate of prior immunologic exposure, reveal potentially relevant immune responses, and set a baseline for future serosurveillance. We analyzed dried blood spots collected in 2021 from a population-weighted representative cross-sectional serosurvey in two communes in the Ouest Department of Haiti. We found lower levels of circulating IgG and IgA antibodies against V. cholerae lipopolysaccharide (LPS, IgG and IgA p<0.0001) in those below 5 years of age compared to those five years and older. Among a subset of patients with higher titers of antibodies, we were unable to detect any functional (vibriocidal) antibodies. In conclusion, the lack of detectable functional antibodies, and age-discordant levels of V. cholerae LPS IgG, suggest that populations in Haiti may be highly susceptible to cholera disease, especially among young children.