Abstract:
White coat pigmentation is a striking phenotype of many domesticated species and has various genetic controls. The Tianzhu White yak, an indigenous breed with a complete white coat, has fascinated Tibetans for centuries. However, the genetic basis of this trait remains unknown. Here, we conducted population genomics analysis and genome-wide association study based on the whole-genome sequencing data of 38 white and 59 non-white-coated yak. The results revealed the presence of KIT-linked Cs alleles characterized by the translocations between chromosomes 6 and 29 in all-white yak. Furthermore, structural variations showed additional duplications of the Cs alleles in white yak compared with colour-sidedness cattle. Interestingly, the Cs alleles associated with the white coat phenotype in yak were found to have introgressed from taurine cattle. Our findings unveil the shared genetic control of the white coat phenotype and its evolution in closely related bovine species.
摘要:
白大衣色素沉着是许多驯化物种的显着表型,并具有各种遗传控制。天祝白牦牛,一个完全白色外套的土著品种,几个世纪以来一直让藏人着迷。然而,这种特征的遗传基础仍然未知。这里,我们基于38例白牦牛和59例非白衣牦牛的全基因组测序数据,进行了群体基因组学分析和全基因组关联研究.结果表明,在全白牦牛中存在KIT连锁的Cs等位基因,其特征是染色体6和29之间的易位。此外,结构变异显示,与色侧牛相比,白牦牛的Cs等位基因有更多重复。有趣的是,发现与牦牛白大衣表型相关的Cs等位基因从牛磺酸牛渗入。我们的发现揭示了白大衣表型的共同遗传控制及其在密切相关的牛物种中的进化。