Abstract：
BACKGROUND: Degenerative disc disease is one of the most common ailments severely affecting the quality of life in elderly population. Cervical intervertebral body fusion devices are utilized to provide stability after surgical intervention for cervical pathology. In this study, we design a biomimetic porous spinal cage, and perform mechanical simulations to study its performances following American Society for Testing and Materials International (ASTM) standards before manufacturing to improve design process and decrease cost and consumption of material.
METHODS: The biomimetic porous Ti-6Al-4 V interbody fusion devices were manufactured by selective laser melting (laser powder bed fusion: LPBF in ISO/ASTM 52900 standard) and subsequently post-processed by using hot isostatic pressing (HIP). Chemical composition, microstructure and the surface morphology were studied. Finite element analysis and in vitro biomechanical test were performed.
RESULTS: The post heat treatment can optimize its mechanical properties, as the stiffness of the cage decreases to reduce the stress shielding effect between two instrumented bodies. After the HIP treatment, the ductility and the fatigue performance are substantially improved. The use of HIP post-processing can be a necessity to improve the physical properties of customized additive manufacturing processed implants.
CONCLUSIONS: In conclusion, we have successfully designed a biomimetic porous intervertebral device. HIP post-treatment can improve the bulk material properties, optimize the device with reduced stiffness, decreased stress shielding effect, while still provide appropriate space for bone growth.
CONCLUSIONS: The biomechanical performance of 3-D printed biomimetic porous intervertebral device can be optimized. The ductility and the fatigue performance were substantially improved, the simultaneously decreased stiffness reduces the stress shielding effect between two instrumented bodies; while the biomimetic porous structures provide appropriate space for bone growth, which is important in the patients with osteoporosis.
METHODS: The biomimetic porous Ti-6Al-4 V interbody fusion devices were manufactured by selective laser melting (laser powder bed fusion: LPBF in ISO/ASTM 52900 standard) and subsequently post-processed by using hot isostatic pressing (HIP). Chemical composition, microstructure and the surface morphology were studied. Finite element analysis and in vitro biomechanical test were performed.
RESULTS: The post heat treatment can optimize its mechanical properties, as the stiffness of the cage decreases to reduce the stress shielding effect between two instrumented bodies. After the HIP treatment, the ductility and the fatigue performance are substantially improved. The use of HIP post-processing can be a necessity to improve the physical properties of customized additive manufacturing processed implants.
CONCLUSIONS: In conclusion, we have successfully designed a biomimetic porous intervertebral device. HIP post-treatment can improve the bulk material properties, optimize the device with reduced stiffness, decreased stress shielding effect, while still provide appropriate space for bone growth.
CONCLUSIONS: The biomechanical performance of 3-D printed biomimetic porous intervertebral device can be optimized. The ductility and the fatigue performance were substantially improved, the simultaneously decreased stiffness reduces the stress shielding effect between two instrumented bodies; while the biomimetic porous structures provide appropriate space for bone growth, which is important in the patients with osteoporosis.
摘要：
背景：椎间盘退行性疾病是严重影响老年人生活质量的最常见疾病之一。颈椎椎间体融合装置用于在颈椎病理学的手术干预后提供稳定性。在这项研究中,我们设计了一个仿生多孔脊柱笼，并在制造前按照美国材料试验协会（ASTM）标准进行机械模拟以研究其性能，以改善设计过程并降低成本和材料消耗。
方法：仿生多孔Ti-6Al-4V椎间融合装置是通过选择性激光熔化（激光粉末床融合：ISO/ASTM52900标准中的LPBF）制造的，随后通过使用热等静压（HIP）进行后处理。化学成分,微观结构和表面形貌进行了研究。进行了有限元分析和体外生物力学测试。
结果：后热处理可以优化其机械性能，随着保持架的刚度降低，以减少两个仪表体之间的应力屏蔽效应。HIP治疗后,延展性和疲劳性能得到了显著改善。使用HIP后处理可以是改善定制增材制造处理的植入物的物理性质的必要条件。
结论：结论：我们成功地设计了一种仿生多孔椎间装置。HIP后处理可以改善散装材料的性能，优化设备，降低刚度，降低应力屏蔽效应，同时仍为骨骼生长提供适当的空间。
结论：可优化3D打印仿生多孔椎间装置的生物力学性能。延性和疲劳性能得到了显著提高，同时降低的刚度降低了两个仪器体之间的应力屏蔽作用；而仿生多孔结构为骨骼生长提供了适当的空间，这对骨质疏松症患者很重要。
方法：仿生多孔Ti-6Al-4V椎间融合装置是通过选择性激光熔化（激光粉末床融合：ISO/ASTM52900标准中的LPBF）制造的，随后通过使用热等静压（HIP）进行后处理。化学成分,微观结构和表面形貌进行了研究。进行了有限元分析和体外生物力学测试。
结果：后热处理可以优化其机械性能，随着保持架的刚度降低，以减少两个仪表体之间的应力屏蔽效应。HIP治疗后,延展性和疲劳性能得到了显著改善。使用HIP后处理可以是改善定制增材制造处理的植入物的物理性质的必要条件。
结论：结论：我们成功地设计了一种仿生多孔椎间装置。HIP后处理可以改善散装材料的性能，优化设备，降低刚度，降低应力屏蔽效应，同时仍为骨骼生长提供适当的空间。
结论：可优化3D打印仿生多孔椎间装置的生物力学性能。延性和疲劳性能得到了显著提高，同时降低的刚度降低了两个仪器体之间的应力屏蔽作用；而仿生多孔结构为骨骼生长提供了适当的空间，这对骨质疏松症患者很重要。
