Abstract：
Persons with spinal cord injury (SCI) can suffer accelerated cognitive aging, even when correcting for mood and concomitant traumatic brain injury. Studies in healthy older adults have shown that myokines (i.e. factors released from muscle tissue during exercise) may improve brain health and cognitive function. Myokines may target chronic neuroinflammation, which is considered part of the mechanism of cognitive decline both in healthy older adults and SCI. An empty systematic review, registered in PROSPERO (CRD42022335873), was conducted as proof of the lack of current research on this topic in people with SCI. Pubmed, Embase, Cochrane and Web of Science were searched, resulting in 387 articles. None were considered eligible for full text screening. Hence, the effect of myokines on cognitive function following SCI warrants further investigation. An in-depth narrative review on the mechanism of SCI-related cognitive aging and the myokine-cognition link was added to substantiate our hypothetical framework. Readers are fully updated on the potential role of exercise as a treatment strategy against cognitive aging in persons with SCI.
摘要：
VINTS,W.A.J,O.Levin,N.Masiulis,J.Verbunt,C.C.M.VanLaake.Myokine可能针对脊髓损伤患者的加速认知衰老：一项系统和局部综述。NEUROSCIBIOBEHAVREVX(X)XXX-XXX,2022年。-脊髓损伤（SCI）的人可能会加速认知老化，即使纠正情绪和伴随的创伤性脑损伤。对健康老年人的研究表明，肌肉因子（即运动过程中从肌肉组织释放的因子）可以改善大脑健康和认知功能。Myokines可能靶向慢性神经炎症，这被认为是健康老年人和SCI认知能力下降机制的一部分。空洞的系统审查，在PROSPERO（CRD42022335873）注册，这证明了SCI患者目前缺乏对这一主题的研究。Pubmed,Embase,搜索了Cochrane和WebofScience,产生387篇文章。没有人被认为有资格进行全文筛选。因此，肌动蛋白对SCI后认知功能的影响值得进一步研究。对SCI相关认知衰老的机制和肌-认知联系进行了深入的叙事回顾，以证实我们的假设框架。读者充分了解了运动作为SCI患者认知衰老的治疗策略的潜在作用。
