Abstract：
Using the M13 phage display, a series of 7- and 12-mer peptides which interact with new sulfobetaine hydrogels are identified. Two peptides each from the 7- and 12-mer peptide libraries bind to the new sulfobetaine hydrogels with high affinity compared to the wild-type phage lacking a dedicated hydrogel binding peptide. This is the first report of peptides binding to zwitterionic sulfobetaine hydrogels and the study therefore opens up the pathway toward new phage or peptide/hydrogel hybrids with high application potential.
摘要：
使用M13噬菌体展示一系列与新的磺基甜菜碱水凝胶相互作用的7聚体和12聚体肽（J.Phys.Chem.B,2021、125、13、3398-3408）被确定。与缺乏专用结合肽的野生型噬菌体相比,来自7聚体和12聚体肽文库的两种肽各自以高亲和力结合新的磺基甜菜碱水凝胶。这是与两性离子磺基甜菜碱水凝胶结合的肽的首次报道，因此该研究开辟了具有高应用潜力的新型噬菌体或肽/水凝胶杂化物的途径。本文受版权保护。保留所有权利。
