Abstract：
OBJECTIVE: To explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson\'s disease dementia (PDD), a meta-analysis was conducted.
METHODS: The relevant studies were identified by searching PubMed, Embase, Web of Science, and Cochrane Collaboration Database up to May 2022. Pooled analysis, sensitivity analysis, and publication bias examination were all conducted. All analyses were performed by using STATA 16.
RESULTS: Twelve studies with a total of 2097 subjects were included. The pooled analysis showed that UA levels were not associated with VaD (WMD = - 10.99 μmol/L, 95% CI (- 48.05, 26.07), P = 0.561) but were associated with PDD (WMD = - 25.22 μmol/L, 95% CI (- 43.47, - 6.97), P = 0.007). The statistical stability and reliability were evaluated using sensitivity analysis and publication bias outcomes.
CONCLUSIONS: UA levels are associated with PDD but not with VaD. This study will help to strengthen our knowledge of the pathophysiologies of VaD and PDD, and promote the development of prevention and treatment strategies.
METHODS: The relevant studies were identified by searching PubMed, Embase, Web of Science, and Cochrane Collaboration Database up to May 2022. Pooled analysis, sensitivity analysis, and publication bias examination were all conducted. All analyses were performed by using STATA 16.
RESULTS: Twelve studies with a total of 2097 subjects were included. The pooled analysis showed that UA levels were not associated with VaD (WMD = - 10.99 μmol/L, 95% CI (- 48.05, 26.07), P = 0.561) but were associated with PDD (WMD = - 25.22 μmol/L, 95% CI (- 43.47, - 6.97), P = 0.007). The statistical stability and reliability were evaluated using sensitivity analysis and publication bias outcomes.
CONCLUSIONS: UA levels are associated with PDD but not with VaD. This study will help to strengthen our knowledge of the pathophysiologies of VaD and PDD, and promote the development of prevention and treatment strategies.
摘要：
目的：探讨尿酸（UA）水平与血管性痴呆（VaD）和帕金森病痴呆（PDD）的关系。进行了荟萃分析.
方法：通过搜索PubMed，Embase,WebofScience,和Cochrane协作数据库，截至2022年5月。汇集分析，敏感性分析，和发表偏倚检查均进行。所有分析均使用STATA16进行。
结果：纳入12项研究，共2097名受试者。汇总分析表明，UA水平与VaD无关（WMD=-10.99μmol/L，95%CI（-48.05，26.07），P=0.561），但与PDD相关（WMD=-25.22μmol/L，95%CI（-43.47，-6.97），P=0.007)。使用敏感性分析和发表偏倚结果评估统计稳定性和可靠性。
结论：UA水平与PDD相关，但与VaD无关。这项研究将有助于加强我们对VaD和PDD病理生理学的认识，并促进预防和治疗策略的发展。
方法：通过搜索PubMed，Embase,WebofScience,和Cochrane协作数据库，截至2022年5月。汇集分析，敏感性分析，和发表偏倚检查均进行。所有分析均使用STATA16进行。
结果：纳入12项研究，共2097名受试者。汇总分析表明，UA水平与VaD无关（WMD=-10.99μmol/L，95%CI（-48.05，26.07），P=0.561），但与PDD相关（WMD=-25.22μmol/L，95%CI（-43.47，-6.97），P=0.007)。使用敏感性分析和发表偏倚结果评估统计稳定性和可靠性。
结论：UA水平与PDD相关，但与VaD无关。这项研究将有助于加强我们对VaD和PDD病理生理学的认识，并促进预防和治疗策略的发展。
