Abstract：
There has been little research on the effects of psychedelics on menstrual and reproductive function, though anecdotal evidence suggests that these compounds may have striking effects on menstrual function in at least a subset of users. Social media and word of mouth were used to seek out individuals who had a history of changes in menstrual function following psychedelic use. Case histories were elicited from three respondents following informed consent. A literature search on the effects of classic psychedelics and related compounds was completed. Three women ranging from 27 to 34 years of age were interviewed and reported three distinct phenomena following the use of classic psychedelics: 1) resumption of menses following amenorrhea, 2) early onset of menses, in particular when psychedelics were used in the mid to late luteal period, and 3) improved menstrual regularity in a woman with irregular cycles who was eventually diagnosed with polycystic ovarian syndrome. The mechanisms behind these effects remain unclear, though they may be mediated via direct or indirect effects of 5-HT2A agonism on the hypothalamic-pituitary-gonadal axis. Although phenomena related to menstrual and reproductive function have been largely overlooked in the psychedelic literature to date, these effects may have therapeutic utility and warrant further study.
摘要：
关于迷幻药对月经和生殖功能的影响的研究很少，尽管轶事证据表明，这些化合物可能对至少一部分使用者的月经功能有显著影响。社交媒体和口碑被用来寻找迷幻药使用后月经功能有变化史的人。病例历史是在知情同意后从三名受访者中得出的。完成了有关经典迷幻药和相关化合物作用的文献检索。采访了三名年龄在27至34岁之间的妇女，并报告了使用经典迷幻药后的三种不同现象：1）闭经后月经恢复，2）月经早期发作，特别是在黄体中后期使用迷幻药时，3）改善月经周期不规则的女性月经规律，最终被诊断为多囊卵巢综合征。这些影响背后的机制尚不清楚，尽管它们可能是通过5-HT2A激动作用对下丘脑-垂体-性腺轴的直接或间接作用介导的。尽管迄今为止，迷幻文献中与月经和生殖功能有关的现象在很大程度上被忽视了，这些效应可能具有治疗效用,值得进一步研究.
