Abstract：
This review explains the origin of the LIV-1 family of zinc transporters, paying attention to how this family of nine human proteins was originally discovered. Structural and functional differences between these nine human LIV-1 family members and the five other ZIP transporters are examined. These differences are both related to aspects of the protein sequence, the conservation of important motifs and to the effect this may have on their overall function. The LIV-1 family are dependent on various post-translational modifications, such as phosphorylation and cleavage, which play an important role in their ability to transport zinc. These modifications and their implications are discussed in detail. Some of these proteins have been implicated in cancer which is examined. Furthermore, some additional areas of potential fruitful discovery are discussed and suggested as worthy of examination in the future.
摘要：
这篇综述解释了锌转运蛋白LIV-1家族的起源，注意这个由9种人类蛋白质组成的家族最初是如何被发现的。检查了这九个人LIV-1家族成员与五个其他ZIP转运蛋白之间的结构和功能差异。这些差异都与蛋白质序列的各个方面有关，重要图案的保存，以及这可能对它们的整体功能产生的影响。LIV-1家族依赖于各种翻译后修饰，比如磷酸化和裂解，它们在运输锌的能力中起着重要作用。详细讨论了这些修改及其含义。这些蛋白质中的一些与所检查的癌症有关。此外，讨论了一些潜在的成果发现的其他领域，并建议将来值得研究。
