Abstract：
Barrett’s esophagus (BE) is a change in the distal esophageal mucosal lining, whereby metaplastic columnar epithelium replaces squamous epithelium of the esophagus. This change represents a pre-malignant mucosal transformation which has a known association with the development of esophageal adenocarcinoma. Gastroesophageal reflux disease is a risk factor for BE, other risk factors include patients who are Caucasian, age > 50 years, central obesity, tobacco use, history of peptic stricture and erosive gastritis. Screening for BE remains selective based on risk factors, a screening program in the general population is not routinely recommended. Diagnosis of BE is established with a combination of endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. We aim to provide a comprehensive review of the epidemiology, pathogenesis, screening and advanced techniques of detecting and eradicating Barrett’s esophagus.
摘要：
Barrett食管（BE）是远端食管粘膜衬里的改变，其中化生柱状上皮取代食管鳞状上皮。这种变化代表了癌前粘膜转化，已知与食管腺癌的发展有关。胃食管反流病是BE的危险因素，其他危险因素包括高加索人，年龄>50岁,中心性肥胖,烟草使用,消化性狭窄和糜烂性胃炎的病史。筛查BE仍然是基于风险因素的选择性，一般人群的筛查计划不被常规推荐.BE的诊断与内镜识别相结合。有针对性的活检,和柱状化生的组织学证实。我们的目标是对流行病学进行全面审查，发病机制，检测和根除巴雷特食管的筛查和先进技术。
