Abstract：
OBJECTIVE: To assess the prevalence of intraosseous cartilaginous lesions in patients with multiple osteochondromas based on total-body (TB) MRI examinations, used for screening purposes.
METHODS: Between 2013 and 2020, TB-MRI examinations were performed in 366 patients with proven multiple osteochondromas syndrome, to rule out malignant progression. For this study, presence, or absence of intraosseous central or eccentrical chondroid lesions, defined as lobulated lesions with low signal intensity on T1-weighted images, replacing bone marrow and high signal intensity equal to fluid on T2-weighted images in the bone marrow of the meta-diaphysis of (one of) the long bones, were recorded in the long bones as part of a TB-MRI protocol.
RESULTS: In 62 patients out of the 366 MO patients (17%), one or more intraosseous chondroid lesions (either enchondroma or atypical cartilaginous tumor) were detected. The age of the patients at time of diagnosis ranged from 17 to 61 years (mean, 36). Size of the lesions varied from 4 to 69 mm (mean, 16.3 mm). The most common location was the proximal femur (n = 29), followed by the distal femur and proximal humerus (n = 18 and n = 10, respectively). In nine of the patients with an intraosseous chondroid lesion, a second and/or third TB-MRI were available during the period of evaluation (mean interval, 2.7 years between the exams). In none of these patients increase of these intraosseous lesions was noticed.
CONCLUSIONS: Intraosseous chondroid lesions (enchondroma and ACT) appear to occur more frequently in MO patients than in the general population. TB-MRI allows to detect these, besides the identification of OC with suspicious features.
METHODS: Between 2013 and 2020, TB-MRI examinations were performed in 366 patients with proven multiple osteochondromas syndrome, to rule out malignant progression. For this study, presence, or absence of intraosseous central or eccentrical chondroid lesions, defined as lobulated lesions with low signal intensity on T1-weighted images, replacing bone marrow and high signal intensity equal to fluid on T2-weighted images in the bone marrow of the meta-diaphysis of (one of) the long bones, were recorded in the long bones as part of a TB-MRI protocol.
RESULTS: In 62 patients out of the 366 MO patients (17%), one or more intraosseous chondroid lesions (either enchondroma or atypical cartilaginous tumor) were detected. The age of the patients at time of diagnosis ranged from 17 to 61 years (mean, 36). Size of the lesions varied from 4 to 69 mm (mean, 16.3 mm). The most common location was the proximal femur (n = 29), followed by the distal femur and proximal humerus (n = 18 and n = 10, respectively). In nine of the patients with an intraosseous chondroid lesion, a second and/or third TB-MRI were available during the period of evaluation (mean interval, 2.7 years between the exams). In none of these patients increase of these intraosseous lesions was noticed.
CONCLUSIONS: Intraosseous chondroid lesions (enchondroma and ACT) appear to occur more frequently in MO patients than in the general population. TB-MRI allows to detect these, besides the identification of OC with suspicious features.
摘要：
目的：根据全身（TB）MRI检查评估多发性骨软骨瘤患者骨内软骨病变的患病率，用于筛选目的。
方法：在2013年至2020年之间，对366例确诊为多发性骨软骨瘤综合征的患者进行了TB-MRI检查，排除恶性进展.对于这项研究，存在,或没有骨内中央或偏心软骨样病变，定义为T1加权图像上具有低信号强度的分叶状病变，在（其中之一）长骨的中段骨干的骨髓中的T2加权图像上替换骨髓和等于液体的高信号强度，作为TB-MRI方案的一部分记录在长骨中。
结果：在366名MO患者中，有62名患者（17％），检测到一个或多个骨内软骨样病变（内生软骨瘤或非典型软骨瘤）。患者在诊断时的年龄范围为17至61岁(平均，36).病变的大小从4到69毫米不等(平均，16.3mm)。最常见的位置是股骨近端（n=29），其次是股骨远端和肱骨近端（分别为n=18和n=10）。在9例骨内软骨样病变患者中，在评估期间可获得第二次和/或第三次TB-MRI(平均间隔时间，考试之间的2.7年）。在这些患者中，均未发现这些骨内病变的增加。
结论：骨内软骨样病变（内软骨瘤和ACT）在MO患者中的发生频率高于一般人群。TB-MRI允许检测这些，除了识别具有可疑特征的OC。
方法：在2013年至2020年之间，对366例确诊为多发性骨软骨瘤综合征的患者进行了TB-MRI检查，排除恶性进展.对于这项研究，存在,或没有骨内中央或偏心软骨样病变，定义为T1加权图像上具有低信号强度的分叶状病变，在（其中之一）长骨的中段骨干的骨髓中的T2加权图像上替换骨髓和等于液体的高信号强度，作为TB-MRI方案的一部分记录在长骨中。
结果：在366名MO患者中，有62名患者（17％），检测到一个或多个骨内软骨样病变（内生软骨瘤或非典型软骨瘤）。患者在诊断时的年龄范围为17至61岁(平均，36).病变的大小从4到69毫米不等(平均，16.3mm)。最常见的位置是股骨近端（n=29），其次是股骨远端和肱骨近端（分别为n=18和n=10）。在9例骨内软骨样病变患者中，在评估期间可获得第二次和/或第三次TB-MRI(平均间隔时间，考试之间的2.7年）。在这些患者中，均未发现这些骨内病变的增加。
结论：骨内软骨样病变（内软骨瘤和ACT）在MO患者中的发生频率高于一般人群。TB-MRI允许检测这些，除了识别具有可疑特征的OC。
