Emerging Biomarkers in Alcohol-associated Hepatitis.

酒精相关性肝炎的新兴生物标志物。

• 发表时间: Jan-Feb 2023
• 来源期刊: J Clin Exp Hepatol
• DOI: 10.1016/j.jceh.2022.07.246
• PMID: 36647419
• 文章类型: Journal Article
• 作者列表: Im GY

关键词: AH, Alcohol-associated hepatitis; ALD, alcohol-associated liver disease; ASCA, anti–Saccharomyces cerevisiae antibodies; AUC, area under the curve; FGF, fibroblast growth factor; GAHS, Glasgow alcohol-associated hepatitis score; HCC, hepatocellular carcinoma; MELD, model for end-stage liver disease; NASH, non-alcohol-associated steatohepatitis; PPV, positive predictive value; PT, prothrombin time; VCTE, vibration-controlled transient elastography; alcohol-associated hepatitis; biomarkers; cytokines; miRNAs, MicroRNAs; microRNA; microbiome

Abstract

Alcohol-associated hepatitis (AH) is a clinical syndrome of jaundice, abdominal pain, and anorexia due to prolonged heavy alcohol intake. AH is associated with changes in gene expression, cytokines, immune response, and the gut microbiome. There are limited biomarkers to diagnose and prognosticate in AH, but several non-invasive biomarkers are emerging. In this review, clinical risk-stratifying algorithms, promising AH biomarkers like cytokeratin-18 fragments, genetic polymorphisms, and microRNAs will be reviewed.

摘要

酒精相关性肝炎（AH）是黄疸的临床综合征，腹痛,和厌食症由于长期大量饮酒。AH与基因表达的变化有关，细胞因子,免疫反应，和肠道微生物组。在AH中诊断和预测的生物标志物有限，但是一些非侵入性生物标志物正在出现。在这次审查中,临床风险分层算法，有希望的AH生物标志物，如细胞角蛋白18片段，遗传多态性,和microRNA将被审查。