Abstract：
Mulberry leaf (ML) and mulberry leaf extract (MLE) have numerous biological properties, such as regulating sugar and lipid metabolism, reducing blood glucose, and increasing insulin secretion. The aim of this study was to perform a systematic review and meta-analysis of randomized clinical trials to examine the effect of ML/MLE supplementation on glycemic traits in adults, including fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and fasting plasma insulin (FPI). Twelve clinical trials (615 participants) fulfilled the eligibility criteria for the present meta-analysis, which included sensitivity analysis and GRADE (grading of recommendations assessment, development, and evaluation) certainty. Based on the heterogeneity between included studies, a random effects model was applied in the meta-analysis, and the results are expressed as WMD (weighted mean differences) with 95% CI (confidence intervals). Meta-analysis showed that ML/MLE supplementation resulted in a significant reduction in FBG by -0.47 mmol L-1, HbA1c by -2.92 mmol mol-1, and FPI by -0.58 μIU mL-1. In addition, subgroup analysis indicated that long-term supplementation of ML/MLE (≥8 weeks) was more effective for regulation of the glycemic traits in the non-healthy and baseline FPG >6.1 mmol L-1 subgroups. Glycemic regulation by ML/MLE may be attributed to the phytochemicals they contain, which are mainly 1-deoxynojirimycin, flavonoids, phenolics, and polysaccharides.
摘要：
桑叶（ML）和桑叶提取物（MLE）具有许多生物学特性，如调节糖和脂质代谢，降低血糖，增加胰岛素分泌.这项研究的目的是对随机临床试验进行系统评价和荟萃分析，以检查ML/MLE补充剂对成人血糖性状的影响。包括空腹血糖（FBG），糖化血红蛋白（HbA1c），和空腹血浆胰岛素（FPI）。12项临床试验（615名参与者）符合本荟萃分析的资格标准，其中包括敏感性分析和等级(建议评估的分级，发展,和评估)确定性。基于纳入研究之间的异质性，在荟萃分析中应用了随机效应模型，结果表示为WMD（加权平均差），95%CI（置信区间）。Meta分析显示，补充ML/MLE导致FBG显著降低-0.47mmolL-1，HbA1c显著降低-2.92mmolmol-1，FPI显著降低-0.58μIUmL-1。此外,亚组分析表明,在非健康和基线FPG>6.1mmolL-1亚组中,长期补充ML/MLE(≥8周)对血糖性状的调节更有效.ML/MLE的血糖调节可能归因于它们含有的植物化学物质，主要是1-脱氧野蓟霉素，黄酮类化合物，酚类物质,和多糖。
