Abstract：
To investigate the incidence of macular neovascularisation (MNV) subtypes of neovascular age-related macular degeneration (nAMD) and summarise these subtypes\' clinical features in the Chinese population using multimodal imaging.
We retrospectively analysed 506 consecutive treatment-naïve nAMD patients (582 eyes). Incidence of MNV subtypes and clinical features were recorded based on their multimodal images. The classification of MNV subtypes in nAMD patients were referred to Consensus on Neovascular Age-related Macular Degeneration Nonmenclature (CONAN) study group classifications.
460 eyes of 389 nAMD patients were included in our study. 68.5% (315/460) of nAMD eyes were from male. According to CONAN, we identified type 1 macular neovascularisation (MNV) in 61.1% of eyes (281/460), type 2 MNV in 16.3% of eyes (75/460), type 3 MNV in 2.0% of eyes (9/460), mixed type 1 and type 2 MNV in 20.6% of eyes (95/460). 58% of eyes (267/460) were diagnosed as polypoidal choroidal vasculopathy lesions (PCV). 45.2% of eyes (208/460) with PCV lesions were type 1 MNV and 12.8% of eyes (59/460) with PCV lesions were co-occurred with type 2 MNV.
Based on the consensus anatomical classification system developed by the CONAN Study Group, we updated the incidence of MNV subtypes and found that PCV was the most common subtype and type 3 MNV was the least common subtype among Chinese nAMD patients. In addition, the co-occurrence of PCV and type 2 MNV was typically observed, and its frequency was reported in our study.
We retrospectively analysed 506 consecutive treatment-naïve nAMD patients (582 eyes). Incidence of MNV subtypes and clinical features were recorded based on their multimodal images. The classification of MNV subtypes in nAMD patients were referred to Consensus on Neovascular Age-related Macular Degeneration Nonmenclature (CONAN) study group classifications.
460 eyes of 389 nAMD patients were included in our study. 68.5% (315/460) of nAMD eyes were from male. According to CONAN, we identified type 1 macular neovascularisation (MNV) in 61.1% of eyes (281/460), type 2 MNV in 16.3% of eyes (75/460), type 3 MNV in 2.0% of eyes (9/460), mixed type 1 and type 2 MNV in 20.6% of eyes (95/460). 58% of eyes (267/460) were diagnosed as polypoidal choroidal vasculopathy lesions (PCV). 45.2% of eyes (208/460) with PCV lesions were type 1 MNV and 12.8% of eyes (59/460) with PCV lesions were co-occurred with type 2 MNV.
Based on the consensus anatomical classification system developed by the CONAN Study Group, we updated the incidence of MNV subtypes and found that PCV was the most common subtype and type 3 MNV was the least common subtype among Chinese nAMD patients. In addition, the co-occurrence of PCV and type 2 MNV was typically observed, and its frequency was reported in our study.
摘要：
目的：研究新生血管性年龄相关性黄斑变性（nAMD）的黄斑新生血管化（MNV）亚型的发生率，并使用多模态成像技术总结中国人群中这些亚型的临床特征。
方法：我们回顾性分析了506例连续治疗初治nAMD患者（582只眼）。根据多模态图像记录MNV亚型和临床特征的发生率。nAMD患者MNV亚型的分类参考新生血管性年龄相关性黄斑变性非脑膜炎性共识（CONAN）研究组分类。
结果：我们的研究纳入了389例nAMD患者的460只眼。68.5%(315/460)的nAMD眼来自男性。根据CONAN,我们发现1型黄斑新生血管（MNV）在61.1％的眼睛（281/460），2型MNV在16.3%的眼睛(75/460)，3型MNV占眼睛的2.0％（9/460），1型和2型MNV混合型占20.6%(95/460)。58％的眼睛（267/460）被诊断为息肉状脉络膜血管病变（PCV）。45.2％的PCV病变眼（208/460）为1型MNV，12.8％的PCV病变眼（59/460）与2型MNV并存。
结论：基于CONAN研究组开发的共识解剖分类系统，我们更新了MNV亚型的发生率,发现在中国nAMD患者中,PCV是最常见的亚型,3型MNV是最不常见的亚型.此外,通常观察到PCV和2型MNV的共存，我们的研究报告了它的频率。
方法：我们回顾性分析了506例连续治疗初治nAMD患者（582只眼）。根据多模态图像记录MNV亚型和临床特征的发生率。nAMD患者MNV亚型的分类参考新生血管性年龄相关性黄斑变性非脑膜炎性共识（CONAN）研究组分类。
结果：我们的研究纳入了389例nAMD患者的460只眼。68.5%(315/460)的nAMD眼来自男性。根据CONAN,我们发现1型黄斑新生血管（MNV）在61.1％的眼睛（281/460），2型MNV在16.3%的眼睛(75/460)，3型MNV占眼睛的2.0％（9/460），1型和2型MNV混合型占20.6%(95/460)。58％的眼睛（267/460）被诊断为息肉状脉络膜血管病变（PCV）。45.2％的PCV病变眼（208/460）为1型MNV，12.8％的PCV病变眼（59/460）与2型MNV并存。
结论：基于CONAN研究组开发的共识解剖分类系统，我们更新了MNV亚型的发生率,发现在中国nAMD患者中,PCV是最常见的亚型,3型MNV是最不常见的亚型.此外,通常观察到PCV和2型MNV的共存，我们的研究报告了它的频率。
