PDF(Pubmed)
Abstract：
Vancomycin is recommended for the treatment of skin and soft tissue infections (SSTI) and bone and joint infections (BJI). However, a detailed investigation of the pharmacokinetic profile and optimal dosing regimens of vancomycin in pediatric patients with SSTI and BJI is lacking. We successfully developed a new PopPK model of vancomycin in this population by using scavenged blood samples with the typical values for clearance (CL) of 0.14 L/h/kg and volume of distribution (V) of 0.5 L/kg. Body weight was confirmed as the significant covariate on CL and V. The optimal dosing regimens of 75 mg/kg/day and 80 mg/kg/day were recommended for this specific population.
摘要：
万古霉素被推荐用于治疗皮肤和软组织感染(SSTI)和骨和关节感染(BJI)。然而,目前尚缺乏对SSTI和BJI儿科患者中万古霉素的药代动力学特征和最佳给药方案的详细研究.我们通过使用清除率（CL）的典型值为0.14L/h/kg，分布体积（V）为0.5L/kg的清除血液样品，成功开发了该人群中万古霉素的新PopPK模型。体重被证实为CL和V的显著协变量。对于该特定群体,推荐75mg/kg/天和80mg/kg/天的最佳给药方案。
