Abstract：
Studies focusing on the relationship between gastric volume and facemask oxygenation without ventilation during apnea in anesthesia induction are scarce. This study compared the change in gastric volume during apnea in anesthesia induction using facemask ventilation and facemask oxygenation without ventilation in adults undergoing laparoscopic surgery.
In this prospective, randomized, double-blinded trial, 70 adults undergoing laparoscopic surgery under general anesthesia were divided into two groups to receive facemask oxygenation with and without ventilation for 60 seconds after loss of consciousness. Before anesthesia induction and after endotracheal intubation, the gastric antral cross-sectional area was measured with ultrasound imaging. Arterial blood gases were tested at baseline (T1), after preoxygenation (T2), after loss of consciousness (T3), and before and after endotracheal intubation (T4 and T5, respectively).
Sixty patients were included (ventilation n = 30; non ventilation n = 30, 10 patients were excluded). The median [IQR] change of gastric antral cross-sectional area in ventilation group was significantly higher than in non ventilation group (0.83 [0.20 to 1.54] vs. 0.10 [- 0.11 to 0.56] cm2, P = 0.001). At T4 and T5, the PaO2 in ventilation group was significantly higher than in non ventilation group (T4: 391.83 ± 61.53 vs. 336.23 ± 74.99 mmHg, P < 0.01; T5: 364.00 ± 58.65 vs. 297.13 ± 86.95 mmHg, P < 0.01), while the PaCO2 in non ventilation group was significantly higher (T4: 46.57 ± 5.78 vs. 37.27 ± 6.10 mmHg, P < 0.01; T5: 48.77 ± 6.59 vs. 42.63 ± 6.03 mmHg, P < 0.01) and the pH value in non ventilation group was significantly lower (T4: 7.35 ± 0.029 vs 7.42 ± 0.047, P < 0.01; T5: 7.34 ± 0.033 vs 7.39 ± 0.044, P < 0.01). At T4, the HCO3- in non ventilation group was significantly higher (25.79 ± 2.36 vs. 23.98 ± 2.18 mmol l- 1, P < 0.01).
During apnoea, the increase in gastric volume was milder in patients undergoing facemask oxygenation without ventilation than with positive pressure ventilation.
ChiCTR2100054193, 10/12/2021, Title: \"Effect of positive pressure and non-positive pressure ventilation on gastric volume during induction of general anesthesia in laparoscopic surgery: a randomized controlled trial\". Website: https://www.chictr.ogr.cn .
In this prospective, randomized, double-blinded trial, 70 adults undergoing laparoscopic surgery under general anesthesia were divided into two groups to receive facemask oxygenation with and without ventilation for 60 seconds after loss of consciousness. Before anesthesia induction and after endotracheal intubation, the gastric antral cross-sectional area was measured with ultrasound imaging. Arterial blood gases were tested at baseline (T1), after preoxygenation (T2), after loss of consciousness (T3), and before and after endotracheal intubation (T4 and T5, respectively).
Sixty patients were included (ventilation n = 30; non ventilation n = 30, 10 patients were excluded). The median [IQR] change of gastric antral cross-sectional area in ventilation group was significantly higher than in non ventilation group (0.83 [0.20 to 1.54] vs. 0.10 [- 0.11 to 0.56] cm2, P = 0.001). At T4 and T5, the PaO2 in ventilation group was significantly higher than in non ventilation group (T4: 391.83 ± 61.53 vs. 336.23 ± 74.99 mmHg, P < 0.01; T5: 364.00 ± 58.65 vs. 297.13 ± 86.95 mmHg, P < 0.01), while the PaCO2 in non ventilation group was significantly higher (T4: 46.57 ± 5.78 vs. 37.27 ± 6.10 mmHg, P < 0.01; T5: 48.77 ± 6.59 vs. 42.63 ± 6.03 mmHg, P < 0.01) and the pH value in non ventilation group was significantly lower (T4: 7.35 ± 0.029 vs 7.42 ± 0.047, P < 0.01; T5: 7.34 ± 0.033 vs 7.39 ± 0.044, P < 0.01). At T4, the HCO3- in non ventilation group was significantly higher (25.79 ± 2.36 vs. 23.98 ± 2.18 mmol l- 1, P < 0.01).
During apnoea, the increase in gastric volume was milder in patients undergoing facemask oxygenation without ventilation than with positive pressure ventilation.
ChiCTR2100054193, 10/12/2021, Title: \"Effect of positive pressure and non-positive pressure ventilation on gastric volume during induction of general anesthesia in laparoscopic surgery: a randomized controlled trial\". Website: https://www.chictr.ogr.cn .
摘要：
背景：关于在麻醉诱导中呼吸暂停期间胃容量与无通气的面罩氧合之间关系的研究很少。这项研究比较了成人腹腔镜手术中使用面罩通气和无通气的面罩氧合麻醉诱导时呼吸暂停期间胃体积的变化。
方法：在此前瞻性中，随机化，双盲试验,将70名在全身麻醉下接受腹腔镜手术的成年人分为两组，在意识丧失后60秒接受有通气和无通气的面罩氧合。麻醉诱导前和气管插管后，用超声成像测量胃窦横截面积.在基线（T1）测试动脉血气，预充氧后（T2），意识丧失（T3）后，气管插管前后（分别为T4和T5）。
结果：纳入60例患者（通气n=30；非通气n=30，排除10例）。通气组胃窦横截面积的中位数[IQR]变化明显高于非通气组（0.83[0.20to1.54]vs.0.10[-0.11至0.56]cm2,P=0.001)。在T4和T5时，通气组的PaO2明显高于非通气组（T4：391.83±61.53vs.336.23±74.99mmHg,P<0.01;T5:364.00±58.65vs.297.13±86.95mmHg，P<0.01),而非通气组的PaCO2明显升高（T4：46.57±5.78vs.37.27±6.10mmHg,P<0.01;T5：48.77±6.59vs.42.63±6.03mmHg,P<0.01），非通气组pH值明显降低（T4：7.35±0.029vs7.42±0.047，P<0.01；T5：7.34±0.033vs7.39±0.044，P<0.01）。在T4时，非通气组的HCO3-显着升高（25.79±2.36vs.23.98±2.18mmol1-1，P<0.01）。
结论：在呼吸暂停期间，与正压通气相比,在不进行面罩氧合的患者中,胃容量增加较轻.
背景：ChiCTR2100054193，2021年10月12日，标题：“腹腔镜手术中全身麻醉诱导期间正压和非正压通气对胃容量的影响：一项随机对照试验”。网站：https://www.chictr.ogr.cn.
方法：在此前瞻性中，随机化，双盲试验,将70名在全身麻醉下接受腹腔镜手术的成年人分为两组，在意识丧失后60秒接受有通气和无通气的面罩氧合。麻醉诱导前和气管插管后，用超声成像测量胃窦横截面积.在基线（T1）测试动脉血气，预充氧后（T2），意识丧失（T3）后，气管插管前后（分别为T4和T5）。
结果：纳入60例患者（通气n=30；非通气n=30，排除10例）。通气组胃窦横截面积的中位数[IQR]变化明显高于非通气组（0.83[0.20to1.54]vs.0.10[-0.11至0.56]cm2,P=0.001)。在T4和T5时，通气组的PaO2明显高于非通气组（T4：391.83±61.53vs.336.23±74.99mmHg,P<0.01;T5:364.00±58.65vs.297.13±86.95mmHg，P<0.01),而非通气组的PaCO2明显升高（T4：46.57±5.78vs.37.27±6.10mmHg,P<0.01;T5：48.77±6.59vs.42.63±6.03mmHg,P<0.01），非通气组pH值明显降低（T4：7.35±0.029vs7.42±0.047，P<0.01；T5：7.34±0.033vs7.39±0.044，P<0.01）。在T4时，非通气组的HCO3-显着升高（25.79±2.36vs.23.98±2.18mmol1-1，P<0.01）。
结论：在呼吸暂停期间，与正压通气相比,在不进行面罩氧合的患者中,胃容量增加较轻.
背景：ChiCTR2100054193，2021年10月12日，标题：“腹腔镜手术中全身麻醉诱导期间正压和非正压通气对胃容量的影响：一项随机对照试验”。网站：https://www.chictr.ogr.cn.
