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Abstract：
This study aimed to assess the clinical usefulness of widefield swept source optical coherence tomography angiography (WF SS-OCTA) for detecting microvasculature lesions in diabetic retinopathy (DR) by comparing it with ultra-widefield fluorescein angiography (UWFFA) and to investigate the effect of panretinal photocoagulation (PRP) on posterior vitreous detachment (PVD) status.
Patients with severe non-proliferative DR (NPDR) or proliferative DR (PDR) who were initially treated with PRP were enrolled. They underwent WF SS-OCTA with a 12×12-mm scan pattern of five visual fixations at baseline and at least a 3-month follow-up after PRP treatment. Patients with no contraindications underwent imaging with UWFFA within a week. Images were evaluated using two methods for the areas of the visible field of view (FOV), non-perfusion area (NPA), presence of neovascularization of the disc (NVD), neovascularization elsewhere (NVE), and PVD status.
In total, 44 eyes of 28 patients with DR that were initially treated with PRP were analyzed. The FOV of the UWFFA was significantly wider than that of the WF SS-OCTA. The quantitative measurement of the NPAs was consistent between the two methods. NPAs more than 5DA outside the panoramic OCTA imaging area were detected in 1 eye with NPDR (8.3%) and in 10 eyes with PDR (47.8%). WF SS-OCTA had high detection rates for NVDs and NVEs, with a low rate of false positives. After PRP treatment, no eyes indicated progression in the PVD stages around the macula, optical disc, or NVEs at the short follow-up.
WF SS-OCTA is clinically useful for evaluating NPAs and neovascularization in DR. PRP treatment does not induce PVD development in the short term.
Patients with severe non-proliferative DR (NPDR) or proliferative DR (PDR) who were initially treated with PRP were enrolled. They underwent WF SS-OCTA with a 12×12-mm scan pattern of five visual fixations at baseline and at least a 3-month follow-up after PRP treatment. Patients with no contraindications underwent imaging with UWFFA within a week. Images were evaluated using two methods for the areas of the visible field of view (FOV), non-perfusion area (NPA), presence of neovascularization of the disc (NVD), neovascularization elsewhere (NVE), and PVD status.
In total, 44 eyes of 28 patients with DR that were initially treated with PRP were analyzed. The FOV of the UWFFA was significantly wider than that of the WF SS-OCTA. The quantitative measurement of the NPAs was consistent between the two methods. NPAs more than 5DA outside the panoramic OCTA imaging area were detected in 1 eye with NPDR (8.3%) and in 10 eyes with PDR (47.8%). WF SS-OCTA had high detection rates for NVDs and NVEs, with a low rate of false positives. After PRP treatment, no eyes indicated progression in the PVD stages around the macula, optical disc, or NVEs at the short follow-up.
WF SS-OCTA is clinically useful for evaluating NPAs and neovascularization in DR. PRP treatment does not induce PVD development in the short term.
摘要：
UNASSIGNED：本研究旨在通过与超场宽荧光素血管造影术（UWFFA）比较，评估宽视场扫描源光学相干断层扫描血管造影（WFSS-OCTA）在检测糖尿病性视网膜病变（DR）中的临床实用性，并研究全视网膜光凝（PRP）对玻璃体后脱离（PVD）状态的影响。
UNASSIGNED：纳入最初接受PRP治疗的重度非增殖性DR（NPDR）或增殖性DR（PDR）患者。他们接受了WFSS-OCTA，在基线时进行了5次视觉固定的12×12-mm扫描，并在PRP治疗后进行了至少3个月的随访。没有禁忌症的患者在一周内接受UWFFA成像。使用两种方法对可见视野(FOV)区域的图像进行评估，非灌注面积（NPA），存在椎间盘新生血管形成（NVD），其他地方的新生血管形成（NVE），和PVD状态。
未经批准：总共，分析了最初接受PRP治疗的28例DR患者的44只眼。UWFFA的FOV明显比WFSS-OCTA宽。NPA的定量测量在两种方法之间是一致的。在1只具有NPDR的眼睛（8.3％）和10只具有PDR的眼睛（47.8％）中，在全景OCTA成像区域之外检测到NPAs超过5DA。WFSS-OCTA对NVD和NVE的检出率高，假阳性率低。PRP治疗后,没有眼睛显示黄斑周围PVD阶段的进展，光盘,或在短期随访中的NVE。
未经证实：WFSS-OCTA在临床上可用于评估DR中的NPAs和新生血管形成。PRP治疗在短期内不诱导PVD发展。
UNASSIGNED：纳入最初接受PRP治疗的重度非增殖性DR（NPDR）或增殖性DR（PDR）患者。他们接受了WFSS-OCTA，在基线时进行了5次视觉固定的12×12-mm扫描，并在PRP治疗后进行了至少3个月的随访。没有禁忌症的患者在一周内接受UWFFA成像。使用两种方法对可见视野(FOV)区域的图像进行评估，非灌注面积（NPA），存在椎间盘新生血管形成（NVD），其他地方的新生血管形成（NVE），和PVD状态。
未经批准：总共，分析了最初接受PRP治疗的28例DR患者的44只眼。UWFFA的FOV明显比WFSS-OCTA宽。NPA的定量测量在两种方法之间是一致的。在1只具有NPDR的眼睛（8.3％）和10只具有PDR的眼睛（47.8％）中，在全景OCTA成像区域之外检测到NPAs超过5DA。WFSS-OCTA对NVD和NVE的检出率高，假阳性率低。PRP治疗后,没有眼睛显示黄斑周围PVD阶段的进展，光盘,或在短期随访中的NVE。
未经证实：WFSS-OCTA在临床上可用于评估DR中的NPAs和新生血管形成。PRP治疗在短期内不诱导PVD发展。
