Abstract：
OBJECTIVE: The current study aimed to comprehensively evaluate the potential effects of mulberry consumption on cardiometabolic risk factors in adults.
METHODS: Relevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.
RESULTS: The quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.
CONCLUSIONS: The current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.
METHODS: Relevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.
RESULTS: The quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.
CONCLUSIONS: The current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.
摘要：
目的：本研究旨在全面评估食用桑树对成年人心脏代谢危险因素的潜在影响。
方法：从SCOPUS系统检索了截至2021年1月的相关文章，PubMed/MEDLINE,EMBASE,和WebofScience数据库。我们纳入了所有随机对照试验（RCTs），调查桑桑消费对各种心脏代谢危险因素的影响。
结果：对12项符合条件的随机对照试验进行的定量荟萃分析显示，桑树消费对血红蛋白A1c（HbA1c）有显著的降低作用（加权平均差[WMD]：-0。55，95%CI：-1.08，-0.02，p=0.044），血清总胆固醇（TC）（WMD：-13.13mg/dl，95%CI：-19.06，-7.20，p<0.001），低密度脂蛋白水平（LDL-C）（WMD：-8.84mg/dl，95%CI：-13.26，-4.42，p<0.001），甘油三酯（TG）（WMD：-19.67mg/dl，95％CI：-30.13，-9.22，p<0.001）和C反应蛋白（CRP）（WMD：-1.60，mg/L，95%CI：-3.07，-0.12，p=0.034）。此外，每天摄入>300mg桑树对血清高密度脂蛋白水平（HDL-C）具有有利作用。然而,桑树干预组其他因素与对照组比较差异无统计学意义。
结论：目前的系统评价和荟萃分析显示，在饮食中加入桑树可能会有利地影响几个心脏代谢危险因素。
方法：从SCOPUS系统检索了截至2021年1月的相关文章，PubMed/MEDLINE,EMBASE,和WebofScience数据库。我们纳入了所有随机对照试验（RCTs），调查桑桑消费对各种心脏代谢危险因素的影响。
结果：对12项符合条件的随机对照试验进行的定量荟萃分析显示，桑树消费对血红蛋白A1c（HbA1c）有显著的降低作用（加权平均差[WMD]：-0。55，95%CI：-1.08，-0.02，p=0.044），血清总胆固醇（TC）（WMD：-13.13mg/dl，95%CI：-19.06，-7.20，p<0.001），低密度脂蛋白水平（LDL-C）（WMD：-8.84mg/dl，95%CI：-13.26，-4.42，p<0.001），甘油三酯（TG）（WMD：-19.67mg/dl，95％CI：-30.13，-9.22，p<0.001）和C反应蛋白（CRP）（WMD：-1.60，mg/L，95%CI：-3.07，-0.12，p=0.034）。此外，每天摄入>300mg桑树对血清高密度脂蛋白水平（HDL-C）具有有利作用。然而,桑树干预组其他因素与对照组比较差异无统计学意义。
结论：目前的系统评价和荟萃分析显示，在饮食中加入桑树可能会有利地影响几个心脏代谢危险因素。
