Abstract：
UNASSIGNED: The relationship between sodium intake and cardiovascular (CV) events remains unconfirmed. Therefore, we carried out a systematic review and dose-response meta-analysis for evaluating the potential impact of 24-hour sodium excretion on CV risk. Besides, 24-hour sodium excretion was used to replace daily sodium diet intake.
UNASSIGNED: We searched ISI Web of Science, Embase, PubMed, and the Cochrane Library. Our study included cohort studies reporting hazard ratio ( HR). The random-effects model was used for summarizing the total relative risks ( RRs) between the included studies. In addition, the generalized least-squares regression was employed to fit the study model.
UNASSIGNED: A total of 9 studies involving 645,006 participants were included in this study. A significant non-linear relationship was observed between sodium excretion and CV events ( P non-linearity < 0.001). In studies collecting 24-h urine samples, the sodium excretion and CV events risk were associated linearly ( RR: 1.04; 95% CI: 1.01, 1.07).
UNASSIGNED: In a linear dose-response manner, every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%. Further studies are required to validate our conclusions further.
UNASSIGNED: We searched ISI Web of Science, Embase, PubMed, and the Cochrane Library. Our study included cohort studies reporting hazard ratio ( HR). The random-effects model was used for summarizing the total relative risks ( RRs) between the included studies. In addition, the generalized least-squares regression was employed to fit the study model.
UNASSIGNED: A total of 9 studies involving 645,006 participants were included in this study. A significant non-linear relationship was observed between sodium excretion and CV events ( P non-linearity < 0.001). In studies collecting 24-h urine samples, the sodium excretion and CV events risk were associated linearly ( RR: 1.04; 95% CI: 1.01, 1.07).
UNASSIGNED: In a linear dose-response manner, every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%. Further studies are required to validate our conclusions further.
摘要：
未经证实：钠摄入与心血管（CV）事件之间的关系尚未得到证实。因此,我们进行了系统评价和剂量-反应荟萃分析,以评估24小时钠排泄对CV风险的潜在影响.此外,24小时钠排泄用于代替每日钠饮食摄入量。
未经批准：我们搜索了ISIWebofScience,Embase,PubMed,还有Cochrane图书馆.我们的研究包括报告风险比（HR）的队列研究。随机效应模型用于总结纳入研究之间的总相对风险（RR）。此外,采用广义最小二乘回归拟合研究模型.
UNASSIGNED：本研究共纳入9项研究，涉及645,006名参与者。在钠排泄和CV事件之间观察到显著的非线性关系(P非线性<0.001)。在收集24小时尿样的研究中，钠排泄和CV事件风险呈线性关系(RR:1.04;95%CI:1.01,1.07).
未经评估：以线性剂量反应方式，钠摄入量每增加1g,CV事件风险增加高达4%.需要进一步的研究来进一步验证我们的结论。
未经批准：我们搜索了ISIWebofScience,Embase,PubMed,还有Cochrane图书馆.我们的研究包括报告风险比（HR）的队列研究。随机效应模型用于总结纳入研究之间的总相对风险（RR）。此外,采用广义最小二乘回归拟合研究模型.
UNASSIGNED：本研究共纳入9项研究，涉及645,006名参与者。在钠排泄和CV事件之间观察到显著的非线性关系(P非线性<0.001)。在收集24小时尿样的研究中，钠排泄和CV事件风险呈线性关系(RR:1.04;95%CI:1.01,1.07).
未经评估：以线性剂量反应方式，钠摄入量每增加1g,CV事件风险增加高达4%.需要进一步的研究来进一步验证我们的结论。
