%0 Systematic Review
%T 24-Hour Urinary Sodium Excretion Association with Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis.
%A Zhao D
%A Li HM
%A Li CX
%A Zhou B
%J Biomed Environ Sci
%V 35
%N 10
%D Oct 2022 20
%M 36443269
%F 2.831
%R 10.3967/bes2022.119
%X <B>UNASSIGNED: </B>The relationship between sodium intake and cardiovascular (CV) events remains unconfirmed. Therefore, we carried out a systematic review and dose-response meta-analysis for evaluating the potential impact of 24-hour sodium excretion on CV risk. Besides, 24-hour sodium excretion was used to replace daily sodium diet intake.<BR><B>UNASSIGNED: </B>We searched ISI Web of Science, Embase, PubMed, and the Cochrane Library. Our study included cohort studies reporting hazard ratio ( HR). The random-effects model was used for summarizing the total relative risks ( RRs) between the included studies. In addition, the generalized least-squares regression was employed to fit the study model.<BR><B>UNASSIGNED: </B>A total of 9 studies involving 645,006 participants were included in this study. A significant non-linear relationship was observed between sodium excretion and CV events ( P non-linearity < 0.001). In studies collecting 24-h urine samples, the sodium excretion and CV events risk were associated linearly ( RR: 1.04; 95% CI: 1.01, 1.07).<BR><B>UNASSIGNED: </B>In a linear dose-response manner, every 1 g increase in sodium intake was associated with an increased risk of CV events up to 4%. Further studies are required to validate our conclusions further.