PDF(Pubmed)
Abstract：
Previous studies suggested a role for adipokines in ageing and in several age-related diseases. The purpose of our study was to further elucidate adipokines involvement in neurodegeneration, investigating adiponectin, leptin and resistin in Alzheimer\'s disease (AD) and Frontotemporal Dementia (FTD). We enrolled for the study 70 subjects: 26 AD, 21 FTD, and 23 with other neurological (but not neurodegenerative) conditions (CTR, control group). According to a standardized protocol, we measured adipokines plasmatic levels, blood parameters of glucidic and lipidic metabolism, ESR, cerebrospinal fluid (CSF) markers of neurodegeneration (beta-amyloid, total-Tau, phosphorylated-Tau) and anthropometric parameters. In comparison with control group, we found lower resistin concentrations in patients with dementia, and in particular in AD (p < 0.001). In multivariate analysis, AD relative risk was reduced by resistin, when controlling for sex, age and anthropometric/metabolic parameters (RR = 0.71, P < 0.0001). Considering CSF biomarkers, we found a direct correlation between resistin and Aβ1-42 CSF concentration in patients (p < 0.001, r = 0.50). Lower resistin characterized AD patients in our study and AD, but not FTD, diagnosis risk was found to be inversely associated with resistin when controlling for confounders. We hypothesize that resistin-linked metabolic profile has to be reconsidered and further investigated in AD.
摘要：
先前的研究表明，脂肪因子在衰老和几种与年龄相关的疾病中发挥作用。我们研究的目的是进一步阐明脂肪因子参与神经变性，调查脂联素，阿尔茨海默病（AD）和额颞叶痴呆（FTD）中的瘦素和抵抗素。我们招募了70名受试者：26名AD，21FTD,和23患有其他神经系统(但不是神经退行性疾病)(CTR，对照组)。根据标准化的协议,我们测量了脂肪因子的血浆水平，葡萄糖和脂质代谢的血液参数，ESR,脑脊液（CSF）神经变性的标志物（β-淀粉样蛋白，Total-Tau,磷酸化Tau）和人体测量参数。与对照组相比,我们发现痴呆症患者的抵抗素浓度较低，特别是在AD中(p<0.001)。在多变量分析中，抵抗素降低了AD的相对风险，当控制性时，年龄和人体测量/代谢参数（RR=0.71，P<0.0001）。考虑到CSF生物标志物，我们发现患者的抵抗素与Aβ1-42CSF浓度之间存在直接相关性（p<0.001，r=0.50）。在我们的研究中，低抵抗素表现为AD患者和AD，但不是FTD，当控制混杂因素时，发现诊断风险与抵抗素负相关。我们假设必须重新考虑与抵抗素相关的代谢谱，并在AD中进一步研究。
