Abstract：
It is difficult to histologically differentiate extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) from chronic gastritis (CG)/ reactive lymphoid hyperplasia (RLH). To determine whether immunohistochemistry for IRTA1 and MNDA can differentiate gastric MALT lymphoma from CG/RLH, we investigated 81 stomach biopsy specimens [Wotherspoon grade (WG) 1, 11 cases; WG 2, 9 cases; WG 3, 20 cases; WG 4, 31 cases; and WG 5, 10 cases]. According to a previously reported algorithm involving PCR for immunoglobulin heavy (IgH) chain locus rearrangement, all 81 cases were divided into three groups: CG/RLH (55 cases), MALT lymphoma (19 cases) groups, and IgH undetectable group (7 cases). We analyzed the CG/RLH and MALT lymphoma groups. The median percentage of IRTA1-positive cells was 0% (range 0%-90.6%) in the CG/RLH group and 43.5% (range 0%-97.6%) in the MALT lymphoma group (p < 0.0001). The median percentage of MNDA-positive cells was 32.4% (range 0%-97.6%) in the CG/RLH group and 55.1% (range 0%-97.6%) in the MALT lymphoma group (p = 0.0044). These results indicate that immunohistochemistry for IRTA1 and MNDA can help differentiate gastric MALT lymphoma from CG/RLH.
摘要：
很难在组织学上区分粘膜相关淋巴组织的结外边缘区淋巴瘤（MALT淋巴瘤）与慢性胃炎（CG）/反应性淋巴增生（RLH）。为了确定IRTA1和MNDA的免疫组织化学是否可以区分胃MALT淋巴瘤和CG/RLH，我们调查了81例胃活检标本[Wotherspoon分级（WG）1，11例；WG2，9例；WG3，20例；WG4，31例；WG5，10例]。根据先前报道的涉及免疫球蛋白重链（IgH）链基因座重排的PCR算法，将81例患者分为三组：CG/RLH（55例），MALT淋巴瘤（19例）组，IgH检测不到组(7例)。我们分析了CG/RLH和MALT淋巴瘤组。CG/RLH组中IRTA1阳性细胞的中位数百分比为0％（范围为0％-90.6％），MALT淋巴瘤组中为43.5％（范围为0％-97.6％）（p<0.0001）。在CG/RLH组中，MNDA阳性细胞的中位数百分比为32.4％（范围为0％-97.6％），在MALT淋巴瘤组中为55.1％（范围为0％-97.6％）（p=0.0044）。这些结果表明IRTA1和MNDA的免疫组织化学可以帮助区分胃MALT淋巴瘤与CG/RLH。
