Abstract：
Many studies have suggested that folate plays a role in preeclampsia (PE) risks, but few studies have assessed folate-related 1-carbon metabolism (OCM)-related nutrients with the risk of PE. We hypothesized that OCM-related nutrients are associated with PE. A 1:1 matched case-control study was conducted to explore the association between dietary OCM-related nutrients intake and the risk of PE in pregnant Chinese women. Four hundred and forty pairs of pregnant women with PE and hospital-based, healthy pregnant women, matched according to gestational week (±1 week) and age (±3 years), were recruited. Dietary intake was assessed using a validated 78-item semiquantitative food frequency questionnaire. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. Restricted cubic splines were plotted to evaluate the dose-response relationship between dietary OCM-related nutrient intake and the risk of PE. Intake of folate, vitamin B6, vitamin B12, methionine, and total choline were inversely related to the risk of PE after adjustment for covariates (all P trend < .05). Adjusted ORs (95% CIs) for quartile 4 versus quartile 1 were 0.71 (0.55-0.93) for folate, 0.66 (0.50-0.87) for vitamin B6, 0.68 (0.52-0.88) for vitamin B12, 0.77 (0.60-0.81) for methionine, and 0.67 (0.51-0.87) for total choline. This study suggests that dietary OCM-related nutrients intake is associated with lower odds of PE in pregnant Chinese women.
摘要：
许多研究表明，叶酸在先兆子痫（PE）风险中起作用，但很少有研究评估叶酸相关的1碳代谢（OCM）相关营养素与PE的风险。我们假设OCM相关营养素与PE相关。进行了1：1匹配的病例对照研究，以探讨中国孕妇饮食OCM相关营养素摄入量与PE风险之间的关系。四百四十对孕妇以PE和医院为基础，健康的孕妇,根据孕周（±1周）和年龄（±3岁）匹配，被招募。使用经过验证的78项半定量食物频率问卷评估饮食摄入量。多因素条件逻辑回归用于估计比值比（OR）和95％CIs。绘制限制性立方样条曲线以评估膳食OCM相关营养素摄入量与PE风险之间的剂量-反应关系。叶酸摄入量，维生素B6，维生素B12，蛋氨酸，校正协变量后，总胆碱与PE风险呈负相关（所有P趋势<0.05）。四分位数4与四分位数1的校正OR(95%CI)为叶酸的0.71(0.55-0.93)，维生素B6为0.66（0.50-0.87），维生素B12为0.68（0.52-0.88），蛋氨酸为0.77（0.60-0.81），总胆碱为0.67（0.51-0.87）。这项研究表明，膳食OCM相关营养素的摄入与中国孕妇PE的几率较低有关。
