Abstract：
Through a systematic review and meta-analyses, we aimed to analyze the impact of chorionicity on neurodevelopment outcomes.
We conducted a comprehensive search strategy through Medline, Embase, Web of Science, and reference lists of the retrieved studies until August 2022. Studies that examined the association between chorionicity and children\'s neurodevelopment outcomes were included.
Twelve studies were included. Monochorionic (MC) twins increased the odds of neurodevelopment impairment, cerebral palsy compared to dichorionic (DC) twins. The differences in neurodevelopmental impairment and cerebral palsy between the two groups disappeared after excluding infants with twin-twin transfusion (TTTS). After fetoscopic laser surgery (FLS) for MC twins, there were no differences too.
Compared to DC twins, MC twins were associated with an increased risk of neurodevelopment impairment. MC twins complicated by TTTS were at high risk of neurologic disability, and FLS was an acceptable treatment modality for them.
We conducted a comprehensive search strategy through Medline, Embase, Web of Science, and reference lists of the retrieved studies until August 2022. Studies that examined the association between chorionicity and children\'s neurodevelopment outcomes were included.
Twelve studies were included. Monochorionic (MC) twins increased the odds of neurodevelopment impairment, cerebral palsy compared to dichorionic (DC) twins. The differences in neurodevelopmental impairment and cerebral palsy between the two groups disappeared after excluding infants with twin-twin transfusion (TTTS). After fetoscopic laser surgery (FLS) for MC twins, there were no differences too.
Compared to DC twins, MC twins were associated with an increased risk of neurodevelopment impairment. MC twins complicated by TTTS were at high risk of neurologic disability, and FLS was an acceptable treatment modality for them.
摘要：
目的：通过系统评价和荟萃分析，我们旨在分析绒毛膜对神经发育结局的影响.
方法：我们通过Medline进行了全面的搜索策略，Embase,WebofScience,以及2022年8月之前检索到的研究的参考列表。包括检查绒毛膜形成与儿童神经发育结果之间关联的研究。
结果：纳入12项研究。单拓扑（MC）双胞胎增加了神经发育障碍的几率，脑瘫与二胎（DC）双胞胎相比。排除双胎输血（TTTS）婴儿后，两组之间神经发育障碍和脑瘫的差异消失。在对MC双胞胎进行胎儿镜激光手术（FLS）后，也没有差异。
结论：与DC双胞胎相比，MC双胞胎与神经发育障碍的风险增加有关。并发TTTS的MC双胞胎有很高的神经系统残疾风险，FLS是他们可以接受的治疗方式。
方法：我们通过Medline进行了全面的搜索策略，Embase,WebofScience,以及2022年8月之前检索到的研究的参考列表。包括检查绒毛膜形成与儿童神经发育结果之间关联的研究。
结果：纳入12项研究。单拓扑（MC）双胞胎增加了神经发育障碍的几率，脑瘫与二胎（DC）双胞胎相比。排除双胎输血（TTTS）婴儿后，两组之间神经发育障碍和脑瘫的差异消失。在对MC双胞胎进行胎儿镜激光手术（FLS）后，也没有差异。
结论：与DC双胞胎相比，MC双胞胎与神经发育障碍的风险增加有关。并发TTTS的MC双胞胎有很高的神经系统残疾风险，FLS是他们可以接受的治疗方式。
