%0 Meta-Analysis
%T Chorionicity and neurodevelopmental outcomes in twin pregnancy: a systematic review and meta-analysis.
%A Yan S
%A Wang Y
%A Chen Z
%A Zhang F
%J J Perinatol
%V 43
%N 2
%D 02 2023
%M 36333420
%F 3.225
%R 10.1038/s41372-022-01534-y
%X Through a systematic review and meta-analyses, we aimed to analyze the impact of chorionicity on neurodevelopment outcomes.<BR>We conducted a comprehensive search strategy through Medline, Embase, Web of Science, and reference lists of the retrieved studies until August 2022. Studies that examined the association between chorionicity and children's neurodevelopment outcomes were included.<BR>Twelve studies were included. Monochorionic (MC) twins increased the odds of neurodevelopment impairment, cerebral palsy compared to dichorionic (DC) twins. The differences in neurodevelopmental impairment and cerebral palsy between the two groups disappeared after excluding infants with twin-twin transfusion (TTTS). After fetoscopic laser surgery (FLS) for MC twins, there were no differences too.<BR>Compared to DC twins, MC twins were associated with an increased risk of neurodevelopment impairment. MC twins complicated by TTTS were at high risk of neurologic disability, and FLS was an acceptable treatment modality for them.